ON THE POSSIBILITY OF LYSOPHOSPHATIDE FORMATION DURING WALLERIAN DEGENERATION
Article first published online: 4 OCT 2006
Journal of Neurochemistry
Volume 15, Issue 2, pages 93–98, February 1968
How to Cite
Domonkos, J. and Heiner, L. (1968), ON THE POSSIBILITY OF LYSOPHOSPHATIDE FORMATION DURING WALLERIAN DEGENERATION. Journal of Neurochemistry, 15: 93–98. doi: 10.1111/j.1471-4159.1968.tb06179.x
- Issue published online: 4 OCT 2006
- Article first published online: 4 OCT 2006
- (Received/i 10 July/i 1967)
—During an extensive decomposition of phospholipids, at the end of the second week of Wallerian degeneration, the decomposition of glycerophosphatides were studied in detail. In a degenerative process lasting for 2 weeks about one-third of the choline phosphatides, two-thirds of the ethanolamine phosphatides, one-third of the serine phosphatides and one-quarter of the inositol phosphatides, were destroyed.
The amount of lysophosphatidylcholine decreased proportionally to the destruction of choline phosphatide. On the other hand, the amount of lysophosphatides formed from‘kephalin'-containing fatty aldehyde, during the marked destruction of these phospholipids, remained constant or increased to a small extent and its percentage distribution increased 2 or 3 times compared with other phospholipids. Ethanolamine phosphatides having a high fatty aldehyde content can be regarded as mainly responsible for the relative accumulation of lysophosphatides.