Medical Research Council Neuropsychiatric Research Unit, Woodmansterne Road, Carshalton, Surrey.
EFFECT OF TRANQUILIZERS ON REGIONAL DISTRIBUTION OF ASCORBIC ACID IN THE RAT BRAIN
Version of Record online: 4 OCT 2006
Journal of Neurochemistry
Volume 15, Issue 3, pages 195–199, March 1968
How to Cite
Rajalakshmi, R. and Patel, A. J. (1968), EFFECT OF TRANQUILIZERS ON REGIONAL DISTRIBUTION OF ASCORBIC ACID IN THE RAT BRAIN. Journal of Neurochemistry, 15: 195–199. doi: 10.1111/j.1471-4159.1968.tb06195.x
- Issue online: 4 OCT 2006
- Version of Record online: 4 OCT 2006
- (Received 3 October 1967)
—Studies were made of the effects of fluphenazine, chlorpromazine and triflupromazine on tissue concentration, liver synthesis of ascorbic acid and its distribution in different areas of the brain. All the three drugs were found to increase liver concentration and synthesis of the vitamin at 24 hr after administration of a single oral dose of the vitamin, but only fluphenazine was found to increase its concentration in the adrenals and brain; the increase in the latter case was found to vary in different regions of the brain, the olfactory lobes, hypothalamus and residual brain showing maximum increases, andthe basal ganglia, visual cortex and remaining dorsal cortex showing minimum increases. The effects were found to be reversed 72 hr after drug treatment.