Commonwealth Scholar; graduate student, Department of Biochemistry, McGill University.
Article first published online: 4 OCT 2006
Journal of Neurochemistry
Volume 15, Issue 3, pages 201–203, March 1968
How to Cite
Wong, K. P. and Sourkes, T. L. (1968), URIDINE NUCLEOTIDES IN BRAIN. Journal of Neurochemistry, 15: 201–203. doi: 10.1111/j.1471-4159.1968.tb06196.x
An abstract of this work has been presented (Wong and Sourkes, 1967a).
This research has been supported by the Medical Research Council of Canada.
- Issue published online: 4 OCT 2006
- Article first published online: 4 OCT 2006
- (Received 6 June 1967)
—Two uridine nucleotides, UDPG and UDPGA, have been measured in brain by a procedure whereby they are extracted from tissue with subsequent utilization, either directly with (UDPGA) or after dehydrogenation (UDPG), in a glucuronidation reaction with harmol or harmalol as cosubstrate. The concentrations of UDPG and UDPGA in brains of a few species of animals examined are, respectively, 11.5–23.3 μmoles/100 g and 0.7–2.5 μmoles/100 g tissue. The ratios of UDPGA to UDPG range from 4% to 11%. The role and importance of these uridine nucleotides in brain are discussed.