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URIDINE NUCLEOTIDES IN BRAIN*

Authors

  • Kim Ping Wong,

    1. Laboratory of Chemical Neurobiology, Department of Psychiatry, McGill University, Montreal 2, Canada
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    • Commonwealth Scholar; graduate student, Department of Biochemistry, McGill University.

    • Department of Biochemistry, Faculty of Medicine, University of Singapore.

  • T. L. Sourkes

    1. Laboratory of Chemical Neurobiology, Department of Psychiatry, McGill University, Montreal 2, Canada
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  • *

    An abstract of this work has been presented (Wong and Sourkes, 1967a).

  • This research has been supported by the Medical Research Council of Canada.

Abstract

—Two uridine nucleotides, UDPG and UDPGA, have been measured in brain by a procedure whereby they are extracted from tissue with subsequent utilization, either directly with (UDPGA) or after dehydrogenation (UDPG), in a glucuronidation reaction with harmol or harmalol as cosubstrate. The concentrations of UDPG and UDPGA in brains of a few species of animals examined are, respectively, 11.5–23.3 μmoles/100 g and 0.7–2.5 μmoles/100 g tissue. The ratios of UDPGA to UDPG range from 4% to 11%. The role and importance of these uridine nucleotides in brain are discussed.

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