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Abstract

—The ability of subfractions of disrupted synaptosomes to bind tetanus toxin has been studied. Synaptic vesicles had little toxin-fixing capacity, but a fraction believed on morphological appearance and enzymic composition to be rich in external synaptosome membranes had a toxin-fixing capacity about 10 times that of the synaptic vesicles and over twice that of the initial brain homogenate. Mitochondria also had a low toxin-fixing capacity and other membrane fractions had an intermediate value. The results are discussed in relation to the known role of ganglioside in fixing toxin.