Supported by Public Health Service Grants NB-00818 and B-3360 from the National Institute of Neuorological Diseases and Blindness. Additional aid was received from a General Research Support Grant to the University of Wisconsin Medical School from the National Institutes of Health, Division of Research Facilities and Resources.
CEREBRAL AMINO ACIDS AND LIPIDS IN DRUG-INDUCED STATUS EPILEPTICUS*
Article first published online: 4 OCT 2006
Journal of Neurochemistry
Volume 15, Issue 3, pages 215–220, March 1968
How to Cite
Whisler, K. E., Tews, J. K. and Stone, W. E. (1968), CEREBRAL AMINO ACIDS AND LIPIDS IN DRUG-INDUCED STATUS EPILEPTICUS. Journal of Neurochemistry, 15: 215–220. doi: 10.1111/j.1471-4159.1968.tb06199.x
- Issue published online: 4 OCT 2006
- Article first published online: 4 OCT 2006
- (Received 3 July 1967)
—Dogs were given repeated doses of pentylenetetrazol to maintain a condition of status epilepticus for periods of 30–40 min. Analyses of cerebral tissue frozen in situ showed significant increases in alanine, arginine, γ-aminobutyric acid, glycine, histidine, leucine, lysine, phenylalanine, serine, tyrosine, and valine. Decreases occurred in the glutamic and aspartic acid levels. Other measured amino compounds were unchanged. Ammonia was increased, but not more than occurs in seizures of brief duration. A large decrease was noted in the ganglioside fraction, and a decrease also in a fraction containing the lecithins and sphingomyelins. The cephalin, cerebroside–sulphatide, and cholesterol fractions were not affected.
Similar repetitive seizures induced by bemegride and continuing for shorter periods (5–9 min) brought about less extensive changes. Glutamic acid was increased, in contrast to the pentylenetetrazol effect, and the apparent decrease in aspartic acid was not statistically significant. Increases were noted in alanine, γ-aminobutyric acid, lysine, and ammonia. The ganglioside and lecithin-sphingomyelin fractions were decreased.