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LOCALIZATION OF γ-AMINOBUTYRIC-α-OXOGLUTARIC ACID TRANSAMINASE IN MOUSE BRAIN*

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  • *

    This investigation was supported in part by funds from the Max C. Fleischmann Foundation of Nevada, a grant from the National Association for Mental Health, and grant NB-01615 from the National Institute of Neurological Diseases and Blindness, National Institutes of Health.

Abstract

The distribution of γ-aminobutyric-α-oxoglutarate transaminase (GABA-T) has been studied in mouse brain by histochemical visualization on sections, quantitative determination in grossly dissected brain regions, and in subcellular fractions prepared from whole brain homogenates. The results indicate that GABA-T is predominantly a mitochondrial enzyme and that its concentration is particularly high in brain stem areas. The results are discussed in relation to the overall function of the GABA system in the CNS.

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