This project was supported, in part, by U.S. Public Health Service Grant HD 01058 and AM 08775.
BRAIN SEROTONIN CHANGES IN PHENYLALANINE-FED RATS: SYNTHESIS STORAGE AND DEGRADATION1
Article first published online: 4 OCT 2006
Journal of Neurochemistry
Volume 16, Issue 6, pages 999–1005, June 1969
How to Cite
Yuwiler, A. and Geller, E. (1969), BRAIN SEROTONIN CHANGES IN PHENYLALANINE-FED RATS: SYNTHESIS STORAGE AND DEGRADATION. Journal of Neurochemistry, 16: 999–1005. doi: 10.1111/j.1471-4159.1969.tb08990.x
- Issue published online: 4 OCT 2006
- Article first published online: 4 OCT 2006
- Received 9 September 1968
The brain serotonin levels of rats maintained on a 5 % phenylalanine diet rose more slowly (0.18 μ g/g brain/hr) after administration of a monoamine oxidase inhibitor than did serotonin levels of controls (0.41 μ g/g brain/hr). The rate of brain serotonin decline following reserpine or dimethylaminobenzoyl methyl reserpate was the same for both groups as was basal monoamine oxidase activity. Brain uptake of monoamine oxidase inhibitor was also the same for both groups. It was concluded that the decrease in brain serotonin levels in phenylalanine-fed animals was due to decreased serotonin formation rather than enhanced degradation. On the basis of available data it was concluded that both hydroxylase inhibition and inhibited precursor transport were involved.