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THE EFFECT OF VOLATILE ANAESTHETICS ON LEVELS OF METABOLITES AND ON METABOLIC RATE IN BRAIN1

Authors

  • E. A. Brunner,

    1. Department of Anesthesia, Anesthesia Research Center, Northwestern University Medical School, Chicago, Illinois 60611
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  • Janet V. Passonneau,

    1. Department of Anesthesia, Anesthesia Research Center, Northwestern University Medical School, Chicago, Illinois 60611
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    • 2

      Laboratory of Neuropathology and Neuroanatomical Sciences, National Institute of Neurological Diseases and Stroke, National Institutes of Health, Public Health Service, U.S. Department of Health, Education and Welfare, Bethesda, Maryland 20014.

  • C. Molstad

    1. Department of Anesthesia, Anesthesia Research Center, Northwestern University Medical School, Chicago, Illinois 60611
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  • 1

    Supported in part by Research Center Grant U.S.P.H.S. GM-15420.

Abstract—

Anaesthesia with ether, halothane, methoxyflurane (Penthrane) and Ohio 347 (Ethrane) increased the energy stores in mouse brain as much as 1·7-fold above the control values. The greatest increases were observed in glucose and glycogen. Glucose-6-P was increased in some cases and UDP glucose was consistently lower in the anaesthetized animals. Hypothermia in conjunction with anaesthesia modified some of the observed changes. Hypothermia alone was associated with an increase in P-creatine and glucose and a decrease in UDPglucose in the brain.

The cerebral metabolic rate was depressed by all the anaesthetic agents to about 50 per cent of the control value. When the body temperature was lowered to 25°, the cerebral metabolic rate fell to 73 per cent of the control rate. A temperature coefficient of 1·035 was calculated as the fractional change/degree between 25° and 34°.

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