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INHIBITION OF THE BIOSYNTHESIS OF ISOPRENOID COMPOUNDS BY PHENOLIC ACIDS IN THE RAT BRAIN
Article first published online: 4 OCT 2006
DOI: 10.1111/j.1471-4159.1974.tb04326.x
1471-4159/asset/cover.gif?v=1&s=4f99ec10d4bac18b4327882ae87f581a11d8dd49 "Journal of Neurochemistry")
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How to Cite
Ranganathan, S. and Ramasarma, T. (1974), INHIBITION OF THE BIOSYNTHESIS OF ISOPRENOID COMPOUNDS BY PHENOLIC ACIDS IN THE RAT BRAIN. Journal of Neurochemistry, 22: 987–990. doi: 10.1111/j.1471-4159.1974.tb04326.x
Publication History
- Issue published online: 4 OCT 2006
- Article first published online: 4 OCT 2006
- Received 6 August 1973. Accepted 28 November 1973
- Abstract
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Abstract
—The incorporation of [2-14C]mevalonate into nonsaponifiable lipids by rat brain homogenates is inhibited by phenolic acids derived from tyrosine. The phenyl acids derived from phenylalanine are inhibitory only at very high concentrations compared with phenolic acids. The brain is more sensitive to inhibition by the phenolic acids than the liver. These studies indicate a possible role for phenolic acids in the impairment of cerebral sterol metabolism in phenylketonuria.