This work was supported by grants from the National Science Foundation(GB 21435. R.Z.)and the United States Public Health Service (NS 06294. O.Z.S.).
α-AMINOCYCLIC AND BICYCLIC ALKANE CARBOXYLIC ACIDS: DIFFERENTIAL EFFECTS ON SELECTED AMINO ACIDS OF RAT BRAIN CORTEX1
Article first published online: 12 DEC 2006
Journal of Neurochemistry
Volume 23, Issue 6, pages 1201–1206, December 1974
How to Cite
Zand, R., Sellingr, O. Z., Water, R. and Harris, R. (1974), α-AMINOCYCLIC AND BICYCLIC ALKANE CARBOXYLIC ACIDS: DIFFERENTIAL EFFECTS ON SELECTED AMINO ACIDS OF RAT BRAIN CORTEX. Journal of Neurochemistry, 23: 1201–1206. doi: 10.1111/j.1471-4159.1974.tb12218.x
- Issue published online: 12 DEC 2006
- Article first published online: 12 DEC 2006
- (Received 13 February 1974. Accepted 22 May 1974)
Abstract— The intraperitoneal administration of 1-aminocyclopentane carboxylic acid, 1-aminocyclohex-ane carboxylic acid, l-aminocycloheptane carboxylic acid, 1-aminocyclooctane carboxylic acid, exo-2-aminobicyclo(2,2. l)heptane-2-carboxylic acid. endo-2-aminobicyclo(2,2.1)heptane-2-carboxylic acid. 2-aminobicyclo(2.2.2)octane-2-carboxylic acid and 2-aminobicyclo(3,2.l)octane-2-carboxylic acid to 18-day-old male rats selectively perturbed the levels of neutral amino acids in the cerebral cortex. While the effect of the above compounds was rather diversified and usually resulted in a reduction of amino acid levels. marked elevations of the levels of valine and isoleucine were also noted. 1-Aminocycloheptane and cyclooctane carboxylic acids were particularly noteworthy, in that they elicited a marked reduction of the levels of cortical phenylalanine.