α-AMINOCYCLIC AND BICYCLIC ALKANE CARBOXYLIC ACIDS: DIFFERENTIAL EFFECTS ON SELECTED AMINO ACIDS OF RAT BRAIN CORTEX1

Authors

  • R. Zand,

    1. Biophysics Research Division, Institute of Science and Technology. Department of Biological Chemistry, University of Michigan, Ann Arbor. Ml 48105. U.S.A.
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  • O. Z. Sellingr,

    1. Laboratory of Neurochemistry, Mental Health Research Institute, University of Michigan, Ann Arbor. MI 48104. U.S.A.
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  • R. Water,

    1. Biophysics Research Division, Institute of Science and Technology. Department of Biological Chemistry, University of Michigan, Ann Arbor. Ml 48105. U.S.A.
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  • R. Harris

    1. Biophysics Research Division, Institute of Science and Technology. Department of Biological Chemistry, University of Michigan, Ann Arbor. Ml 48105. U.S.A.
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  • 1

    This work was supported by grants from the National Science Foundation(GB 21435. R.Z.)and the United States Public Health Service (NS 06294. O.Z.S.).

Abstract

Abstract— The intraperitoneal administration of 1-aminocyclopentane carboxylic acid, 1-aminocyclohex-ane carboxylic acid, l-aminocycloheptane carboxylic acid, 1-aminocyclooctane carboxylic acid, exo-2-aminobicyclo(2,2. l)heptane-2-carboxylic acid. endo-2-aminobicyclo(2,2.1)heptane-2-carboxylic acid. 2-aminobicyclo(2.2.2)octane-2-carboxylic acid and 2-aminobicyclo(3,2.l)octane-2-carboxylic acid to 18-day-old male rats selectively perturbed the levels of neutral amino acids in the cerebral cortex. While the effect of the above compounds was rather diversified and usually resulted in a reduction of amino acid levels. marked elevations of the levels of valine and isoleucine were also noted. 1-Aminocycloheptane and cyclooctane carboxylic acids were particularly noteworthy, in that they elicited a marked reduction of the levels of cortical phenylalanine.

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