THE MOTOR END-PLATE SPECIFIC FORM OF ACETYLCHOLINESTERASE: APPEARANCE DURING EMBRYOGENESIS AND RE-INNERVATION OF RAT MUSCLE
Article first published online: 4 OCT 2006
Journal of Neurochemistry
Volume 27, Issue 6, pages 1347–1353, December 1976
How to Cite
Vigny, M., Koenig, J. and Rieger, F. (1976), THE MOTOR END-PLATE SPECIFIC FORM OF ACETYLCHOLINESTERASE: APPEARANCE DURING EMBRYOGENESIS AND RE-INNERVATION OF RAT MUSCLE. Journal of Neurochemistry, 27: 1347–1353. doi: 10.1111/j.1471-4159.1976.tb02614.x
- Issue published online: 4 OCT 2006
- Article first published online: 4 OCT 2006
- (Received 29 March 1976. Revised 18 June 1976. Accepted 21 June 1976)
Abstract– We have solubilized three active molecular forms of AChE from rat muscle and have confirmed the presence of one of these forms (EP form, apparent sedimentation coefficient: 16 s) uniquely at the motor end-plate regions of several skeletal muscles. This form was never detected in smooth muscle extracts. In sternocleidomastoïdian muscle it disappeared after denervation and reappeared after re-innervation in the region where nerve and muscle had come in contact. During the embryonic development of hind leg muscles the EP form appeared on the 14th or 15th day of gestation.
The EP form of muscle AchE appears to be an excellent biochemical marker of the neuromuscular junction.