Supported, in part, by the Medical Research Service of the Veterans Administration and by grants 5ROlHD08575 and EDIDA 01 146.
EFFECT OF ALBUMIN BINDING AND AMINO ACID COMPETITION ON TRYPTOPHAN UPTAKE INTO BRAIN1
Article first published online: 4 OCT 2006
Journal of Neurochemistry
Volume 28, Issue 5, pages 1015–1023, May 1977
How to Cite
Yuwiler, A., Oldendorf, W. H., Geller, E. and Braun, L. (1977), EFFECT OF ALBUMIN BINDING AND AMINO ACID COMPETITION ON TRYPTOPHAN UPTAKE INTO BRAIN. Journal of Neurochemistry, 28: 1015–1023. doi: 10.1111/j.1471-4159.1977.tb10664.x
- Issue published online: 4 OCT 2006
- Article first published online: 4 OCT 2006
- (Received 11 March 1976. Accepted 17 November 1976
Abstract— In the present study we examine the influence of pH, palmitate, and neutral amino acids on the passage of tryptophan from blood into brain during a single capillary pass, and on the partitioning of tryptophan between free and albumin-bound forms. The results show that a considerable fraction of albumin-bound tryptophan is stripped from albumin sites during passage, that uptake is concentration-dependent, and that amino acid competition for carrier sites is quantitatively the most important factor in regulating tryptophan uptake into brain. The interaction between tryptophan concentration, tryptophan binding, and competing amino acids is of considerable influence on brain serotonin biosynthesis.