MRC Neurochemical Pharmacology Unit, Department of Pharmacology, Medical School, Hills Road, Cambridge, CB2 2QD.
REGIONAL DISTRIBUTION OF MONOAMINES AND THEIR METABOLITES IN THE HUMAN BRAIN
Version of Record online: 5 OCT 2006
Journal of Neurochemistry
Volume 30, Issue 4, pages 841–848, April 1978
How to Cite
Mackay, A. V. P., Yates, C. M., Wright, A., Hamilton, P. and Davies, P. (1978), REGIONAL DISTRIBUTION OF MONOAMINES AND THEIR METABOLITES IN THE HUMAN BRAIN. Journal of Neurochemistry, 30: 841–848. doi: 10.1111/j.1471-4159.1978.tb10792.x
- Issue online: 5 OCT 2006
- Version of Record online: 5 OCT 2006
- (Received 29 April 1977. Revised 31 August 1977. Accepted 16 September 1977)
Abstract— Noradrenaline (NA), dopamine (DA). 5-hydroxytryptamine (5-HT), 4-hydroxy, 3-methoxy-phenylethylene glycol (MHPG), homovanillic acid (HVA), 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindolylacetic acid (5-HIAA) were measured in twenty areas of post-mortem brain from ten psychiatrically and neurologically normal patients. There was a marked difference, which did not appear to be related to sex, medication, cause of death or time between death and dissection, in amine and metabolite concentrations between brains. In the cortex, 5-HT, MHPG, HVA. DOPAC and S-HIAA were approximately even in their distribution; NA and DA could not be detected. In sub-cortical areas there were clear differences in the distribution of the three amines accompanied by less marked differences in the distribution of their respective metabolites.