DEMONSTRATION OF HIGH AFFINITY HEXOSE UPTAKE IN CEREBRAL CORTEX SLICES

Authors


All correspondence should be addressed to this author. Present address: Department of Biochemistry. University of Bath, Bath BA2 7AY, U.K.

Abstract

Abstract— The high-affinity glucose transport system (Km 0.2–0.4 mm), previously detected in synaptosome preparations, has now been demonstrated to be present in slices of the cerebral cortex incubated in vitro. The kinetic properties of this undirectional uptake process in slices were similar to those exhibited by synaptosomes. The results are discussed with respect to the possible sites of the high affinity and low affinity glucose transport processes in the brain.

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