Cátedra de Farmacología, Escuela de Medicina José Vargas, Universidad Central de Venezuela, Apartado de Correos No. 76359, Caracas 107, Venezuela.
THE EFFECT OF FASTING ON THE METABOLISM OF 5-HYDROXYTRYPTAMINE AND DOPAMINE IN THE BRAIN OF THE MOUSE
Version of Record online: 5 OCT 2006
Journal of Neurochemistry
Volume 33, Issue 2, pages 481–485, August 1979
How to Cite
Fuenmayor, L. D. (1979), THE EFFECT OF FASTING ON THE METABOLISM OF 5-HYDROXYTRYPTAMINE AND DOPAMINE IN THE BRAIN OF THE MOUSE. Journal of Neurochemistry, 33: 481–485. doi: 10.1111/j.1471-4159.1979.tb05178.x
- Issue online: 5 OCT 2006
- Version of Record online: 5 OCT 2006
- (Received 28 September 1978. Revised 5 February 1979. Accepted 23 February 1979)
Abstract— The turnover of 5-hydroxytryptamine in the forebrain and of dopamine in the striatum was studied in mice fasted for 20 h. Such mice showed an increased tissue concentration of 5-hydroxyindoleacetic acid in the forebrain and an increased accumulation of this acid after probenecid. Fasted mice also showed a higher concentration of homovanillic acid in the striatum than fed mice. However, the administration of probenecid produced a smaller increase in homovanillic acid concentration in fasted than in fed mice. The decay of dopamine following α-methyl-p-tyrosine was reduced in fasted mice at 2 h, but not at 1 h or 6 h after administration of the inhibitor. The possibility that fasting increases the activity of some dopaminergic neurones while decreasing the activity of others is considered. The existence of a pool of homovanillic acid at a site within the striatum where the probenecid-sensitive transport is not effective is postulated.