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EFFECT OF PHENYL AND PHENOLIC ACIDS ON MEVALONATE-5-PHOSPHATE KINASE AND MEVALONATE-5-PYROPHOSPHATE DECARBOXYLASE OF THE RAT BRAIN
Article first published online: 5 OCT 2006
DOI: 10.1111/j.1471-4159.1979.tb11095.x
1471-4159/asset/cover.gif?v=1&s=4f99ec10d4bac18b4327882ae87f581a11d8dd49 "Journal of Neurochemistry")
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How to Cite
Bhat, C. S. and Ramasarma, T. (1979), EFFECT OF PHENYL AND PHENOLIC ACIDS ON MEVALONATE-5-PHOSPHATE KINASE AND MEVALONATE-5-PYROPHOSPHATE DECARBOXYLASE OF THE RAT BRAIN. Journal of Neurochemistry, 32: 1531–1537. doi: 10.1111/j.1471-4159.1979.tb11095.x
Publication History
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received 8 August 1978, Revised12 November 1978, Accepted 22 December 1978
- Abstract
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Abstract— Phenyl and phenolic acids are known to inhibit metabolism of mevalonate in rat brain. The site of inhibition has been found to be mevalonate-5-pyrophosphate decarboxylase. Phenolic acids also inhibited mevalonate-5-phosphate kinase on preincubation. The kinetics showed that p-coumaric acid and isoferulic acid were competing with substrates, mevalonate-5-phosphate or mevalonate-5-pyre phosphate, whereas others showed an uncompetitive type of inhibition. Chlorophenoxyisobutyrate, a hypocholesterolaemic drug, had no effect on these enzymes. An improved method for the synthesis of mevalonate-5-phosphate and mevalonate-5-pyrophosphate, labeled at carbon-1, is described.