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Nerve Growth Factor: Biological Significance, Measurement and Distribution


  • G. P. Harper is a Research Fellow of the European Molecular Biology Organization.

Address reprint requests to Dr. G.P. Harper, Department of Neurochemistry, Max Planck Institute for Psychiatry, Am Klopferspitz 18a, 8033 Martinsried/Munich, FRG.


NGF proteins probably act as informational molecules transferred from end organs to the neurons of the sympathetic nervous system. The direct demonstration of the NGF content of most end organs requires assays more sensitive than those currently available. The high levels of NGF produced by some organs are probably of some other physiological significance.