Alterations in γ-Aminobutyric Acid Receptor Sensitivity Following Acute and Chronic Ethanol Treatments
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 34, Issue 2, pages 417–423, February 1980
How to Cite
Ticku, M. K. and Burch, T. (1980), Alterations in γ-Aminobutyric Acid Receptor Sensitivity Following Acute and Chronic Ethanol Treatments. Journal of Neurochemistry, 34: 417–423. doi: 10.1111/j.1471-4159.1980.tb06612.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received July 9, 1979; accepted August 17, 1979.
The effects of acute and chronic ethanol ingestion on the binding of the inhibitory neurotransmitter 3H-γ-aminobutyric acid (GABA) was investigated in inbred strains of mice. Acute effects were analyzed in DBA/2J (alcohol avoiding) and C57BL/6J (alcohol preferring) mice, while chronic effects were analyzed in C57 mice. Acute ethanol (4 g/kg) produced a significant increase in the binding capacity of the low-affinity γ-aminobutyric acid binding site in both C57 (12%) and DBA (23%) mice, without significantly altering other binding parameters. The enhanced binding capacity may be responsible for the behavioral depression associated with ethanol use. Chronically treated C57 mice exhibited a decrease in the density of low-affinity GABA receptor sites. These results suggest the possible involvement of γ-aminobutyric acid synaptic function in the neuropharmacological effects of ethanol. The possibility that chronic ethanol administration may result in adaptation of γ-aminobutyric acid receptors to the continuous presence of ethanol-induced central nervous system depression is discussed.