Hippocampal Free Amino Acids in Alzheimer's Disease
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 35, Issue 5, pages 1246–1249, November 1980
How to Cite
Tarbit, I., Perry, E. K., Perry, R. H., Blessed, G. and Tomlinson, B. E. (1980), Hippocampal Free Amino Acids in Alzheimer's Disease. Journal of Neurochemistry, 35: 1246–1249. doi: 10.1111/j.1471-4159.1980.tb07883.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received January 28, 1980; revised March 24, 1980; accepted May 6, 1980.
The free amino acid content of the hippocampus, obtained at postmortem, has been analysed in cases of Alzheimer's disease and compared with normal cases. There were no significant differences in the levels of 23 amino acids including the transmitter candidates γ-aminobutyric, glutamic or aspartic acids. This finding is interpreted in relation to present knowledge of transmitter pathways in the region of the hippocampus. A tendency for some amino acids to be increased in the Alzheimer group reached statistical significance for arginine. This observation is consistent with increased proteolytic or peptidase activity in Alzheimer's disease.