No Effect of Hyperketonemia on Local Cerebral Glucose Utilization in Conscious Rats
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 38, Issue 6, pages 1637–1641, June 1982
How to Cite
Corddry, D. H., Rapoport, S. I. and London, E. D. (1982), No Effect of Hyperketonemia on Local Cerebral Glucose Utilization in Conscious Rats. Journal of Neurochemistry, 38: 1637–1641. doi: 10.1111/j.1471-4159.1982.tb06644.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received July 28, 1981; accepted December 1, 1981.
- Ketone body;
- Oxidative metabolism;
- Glucose utilization
Abstract: Local cerebral glucose utilization was measured by the [14C]2-deoxy-d-glucose method in conscious control and hyperketonemic rats. Hyperketonemia was induced by 3 days of starvation or by infusion of 3- hydroxybutyrate in fed rats. These treatments produced combined blood ketone body concentrations (acetoacetate + 3-hydroxybutyrate) of from 1.2 to 2.4 mM. Neither treatment significantly affected glucose utilization in any of the 15 brain regions studied. These observations indicate that hyperketonemia in resting, conscious rats does not interfere with brain uptake and phosphorylation of glucose.