Norepinephrine Depletion in the Spinal Cord Gray Matter of Rats with Experimental Allergic Encephalomyelitis
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 40, Issue 6, pages 1771–1773, June 1983
How to Cite
White, S. R., Bhatnagar, R. K. and Bardo, M. T. (1983), Norepinephrine Depletion in the Spinal Cord Gray Matter of Rats with Experimental Allergic Encephalomyelitis. Journal of Neurochemistry, 40: 1771–1773. doi: 10.1111/j.1471-4159.1983.tb08156.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received September 28, 1982; accepted December 29, 1982.
- Spinal cord;
- Experimental allergic encephalomyelitis.
Norepinephrine and dopamine concentrations were determined by radioenzymatic assay in discrete gray matter regions of the spinal cords of rats with experimental allergic encephalomyelitis (EAE). Norepinephrine was depleted in most spinal cord regions of EAE rats compared with controls, whereas dopamine depletion in EAE rats was restricted to the cervical dorsal horn. There was a rostrocaudal gradient of norepinephrine reduction in the spinal cords of the EAE rats with most severe depletion in the lumbar region. The results of this experiment confirmed recent anatomical observations that suggested that catecholamine-fluorescent axons and terminals were damaged in spinal cords of rats with EAE.