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Abbreviations used:
GAB A

δ-Aminobutyric acid

HRP

Horseradish peroxidase

NMDA

N-Methyl-D-aspartate

REFERENCES

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  2. REFERENCES
  • Abdul-Ghani, A. S., Bradford, H. F., Cox, D. W. G., and Dodd, P. R. (1979) Peripheral sensory stimulation and the release of transmitter amino acids in vivo from specific regions of cerebral cortex. Brain Res. 171, 5556.
  • Altschuler, F. R., Neises, G. R., Harmison, G. C., Wenthold, R. J., and Fex, J. (1981) Immunocytochemical localization of as-partate aminotransferase immunoreactivity in cochlear nucleus of the guinea pig. Proc. Natl. Acad. Sci. USA 78, 65536557.
  • Altschuler, R. A., Mosinger, J. L., Harmison, G. G., Parakkal, M. H., and Wenthold, R. J. (1982) Aspartate aminotransferase-like immunoreactivity as a marker for aspartate/glutamate in guinea pig photoreceptors. Nature 298, 657659.
  • Balazs, R., Machiyama, Y., Hammond, B. J., Julian, T., and Richter, D. (1970) The operation of the γ-aminobutyrate bypath of the tricarboxylic acid cycle in brain tissue in vitro. Biochem. J. 116, 445467.
  • Balcar, V. J. and Johnston, G. A. R. (1972) The structural specificity of the high affinity uptake of L-glutamate and L-aspartate by rat brain slices. J. Neurochem. 19, 26572666.
  • Balcar, V. J., and Johnston, G. A. R. (1973) High affinity uptake of transmitters: studies on the uptake of L-aspartate, GABA, L-glutamate and glycine in cat spinal cord. J. Neurochem. 20, 529539.
  • Balcar, V. J., Borg, J., and Mandel, P. (1977) High affinity uptake of L-glutamate and L-aspartate by glial cells. J. Neurochem. 28, 8793.
  • Baughman, R. W. and Gilbert, C. D. (1981) Aspartate and glutamate as possible neurotransmitters in the visual cortex. J. Neurosci. 1, 427439.
  • Baudry, M., Seman, R., Smith, E. W., and Lynch, G. (1983) Regulation by calcium ions of glutamate receptor binding in hip-pocampal slices. Eur. J. Pharmacol. 90, 161166.
  • Berl, S. and Clarke, D. D. (1978) Metabolic compartmentation of the glutamate-glutamine system; glial contribution, in Amino Acids as Chemical Transmitters (Fonnum, F., ed), pp. 691708. Plenum Press, New York .
  • Bennet Logan, W. J., and Snyder, S. W. (1973) Amino acids as central nervous transmitters. The influence of ions, amino acid analogues and ontogeny on transport systems for L-glutamic and L-aspartic acids and glycine into central nervous synaptosomes of the rat. J. Neurochem. 21, 15331550.
  • Berl, S., Lajtha, A., and Waelsch, H. (1961) Amino acid and protein metabolism. VI. Cerebral compartments of glutamic acid metabolism. J. Neurochem. 7, 186197.
  • Berl, S., Takagaki, G., Clarke, D. D., and Waelsch, H. (1962) Metabolic compartments in vivo: ammonia and glutamic acid metabolism in brain and liver. J. Biol. Chem. 237, 25622569.
  • Blaustein, M. P. (1975) Effects of potassium, veratridine and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vivo. J. Physiol. (Lond.) 247, 617653.
  • Bowey, N. G., Brown, D. A., and Marsh, S. (1979) γ-Aminobutyric acid efflux from sympathetic glial cells: effect of depolarizing agents. J. Physiol. (Lond.), 293, 7590.
  • Bradford, H. F. and Ward, H. K. (1976) On glutaminase in mammalian synaptosomes. Brain. Res. 110, 115125.
  • Bradford, H. R., Ward, H. K., and Tomas, A. J. (1978) Glutamine---a major substrate for nerve endings. J. Neurochem. 30, 14531459.
  • Canzek, V. and Reubi, J. C. (1980) The effect of cochlear nerve lesion on the release of glutamate, aspartate and GABA from the cochlear nucleus in vitro. Exp. Brain Res. 38, 437441.
  • Clark, R. M., and Collins, G. G. S. (1975) The spontaneous and potassium-evoked release of endogenous amino acids from the mammalian visual cortex. J. Physiol. (Lond.) 246, 1617.
  • Clark, R. M. and Collins, G. G. S. (1976) The release of endogenous amino acids from the rat visual cortex. J. Physiol. (Lond.), 262, 383400.
  • Clarke, D. D., Ronan, E. J., Dicker, E., and Tirri, L. (1975) Ethanol and its relation to amino acid metabolism in brain, in Metabolic Compartmentation and Neurotransmission (Berl, S., Clarke, D. D., and Schneider, D., eds), pp. 449460. Plenum Press, New York .
  • Collins, G. G. S. (1980) Release of endogenous amino acid neurotransmitter candidates from rat olfactory cortex slices: possible regulatory mechanisms and the effects of pentobarbitone. Brain Res. 190, 517528.
  • Collins, G. G. S. and Probett, G. A. (1981) Aspartate and not glutamate is the likely transmitter of the rat lateral olfactory tract fibres. Brain Res. 201, 231234.
  • Cotman, C. W., Foster, A., and Lanthorn, T. (1981) An overview of glutamate as a neurotransmitter, in Glutamate as a Neu-rotransmitter (DiChiara, G. and Gessa, G. L., eds), pp. 127. Raven Press, New York .
  • Coyle, J. T. (1983) Neurotoxic action of kainic acid. J. Neurochem. 41, 111.
  • Crawford, I. L. and Connor, J. D. (1973) Localization and release of glutamic acid in relation to the hippocampal mossy fibre pathway. Nature 244, 442443.
  • Cremer, J. E., Heath, D. R., Patel, A. J., Balazs, R., and Cavanagh, J. B. (1975) An experimental model of CNS changes associated with chronic liver disease: portocaval anastomosis in the rat, in Metabolic Compartmentation and Neurotransmission (Berl, S., Clarke, D. D., and Schneider, D., eds), pp. 461478. Plenum Press, New York .
  • Cuenod, M., Beaudet, A., Canzek, V., Streit, P., and Reubi, J. C. (1981) Glutamergic pathways in the pigeon and in the rat brain. Adv. Biochem. Psychopharmacol. 27, 5768.
  • Curtis, D. R. and Johnston, G. A. R. (1974) Amino acid transmitters in the mammalian central nervous system. Ergebn. Physiol. 69, 94188.
  • Curtis, D. R. and Watkins, J. C. (1961) The chemical excitation of spinal neurons by certain amino acids. J. Physiol. (Lond.) 166, 114.
  • Davidoff, R. A., Graham, L. T., Shank, R. P., Werman, R., and Aprison, M. H. (1967) Changes in amino acid concentrations associated with loss of spinal interneurons. J. Neurochem. 14, 10251031.
  • Davies, L. P. and Johnston, G. A. R. (1976) Uptake and release of D-and L-aspartate by rat brain slices. J. Neurochem. 26, 10071014.
  • de Barry, J., Langley, O. K., Vincendon, G., and Gombos, G. (1982) L-glutamate and L-glutamine uptake in adult rat cerebellum: an autoradiographic study. Neuroscience 7, 12891297.
  • de Belleroche, J. S. and Bradford, H. F. (1972) Metabolism of beds of mammalian cortical synaptosomes: response to depolarizing influences. J. Neurochem. 19, 525602.
  • de Belleroche, J. S. and Bradford, H. F. (1973) Amino acids in synaptic vesicles from mammalian cerebral cortex: a reappraisal. J. Neurochem. 21, 441451.
  • DiChiara, G., and Gessa, G. L. (1981) Glutamate as a Neurotransmitter. Raven Press, New York .
  • Dolly, J. O., Tse, C. K., Spokes, J. W., and Diniz, C. R. (1978) Effects of β-bungarotoxin and Tityus toxin on uptake and release of neurotransmitters. Biochem. Soc. Trans. 6, 652654.
  • Duce, I. R. and Keen, P. (1983) Selective uptake of [3H]glutamine and [3H]glutahiate into neurons and satellite cells of dorsal root ganglia in vitro. Neuroscience 8, 861866.
  • Ellory, J. C., Jones, S. E. M., and Young, J. D. (1981) Glycine transport in human erythrocytes. J. Physiol. (Lond.) 320, 403422.
  • Engelsen, B. and Fonnum, F. (1982) Effects of hypoglycemia on transmitter and non-transmitter glutamate. Acta Neurol. Scand. (Suppl. 90) 65, 6364.
  • Fagg, G. E., Foster, A. C., Mena, E. E., and Cotman, C. W. (1982) Chloride and calcium ions reveal a pharmacological distinct population of L-glutamate binding sites in synaptic membranes: correspondence between biochemical and electrophysiological data. J. Neurosci. 2, 958965.
  • Fonnum, F. (1968) The distribution of glutamate decarboxylase and aspartate transaminase in subcellular fractions of rat and guinea-pig brain. Biochem. J. 106, 401412.
  • Fonnum, F., (Ed.) (1978) Amino Acids as Chemical Transmitters, NATO Advanced Study Institutes Series, Series A, Life Sciences; Vol. 16. Plenum Press, New York .
  • Fonnum, F. (1981) The turnover of transmitter amino acids with special reference to GABA, in Central Neurotransmitter Turnover. (Pycock, C. J. and Taberner, P. V., eds), pp. 105124. University Park Press, Baltimore .
  • Fonnum, F. and Walaas, I. (1978) The effect of intrahippocampal kainic acid injections and surgical lesions on neurotransmitters in hippocampus and septum. J. Neurochem. 31, 11731181.
  • Fonnum, F, and Walberg, F. (1973) An estimation of the concentration of γ-aminobutyric acid and glutamate decarboxylase in the inhibitory Purkinje axon terminals of the cat. Brain Res. 54, 115127.
  • Fonnum, F., Lund-Karlsen, R., Malthe-Sørenssen, D., Skrede, K. K., and Walaas, I. (1979) Localization of neurotransmitters, particularly glutamate, in hippocampus, septum, nucleus accumbens and superior colliculus. Progr. Brain Res. 51, 167191.
  • Fonnum, F., Lund-Karlsen, R., Malthe-Sørenssen, D., Sterri, S., and Walaas, I. (1980) High affinity transport systems and their role in transmitter action, in The Cell Surface and Neuronal Function, (Cotman, C. W., Poste, G., and Nicholson, G. L., eds), pp. 455504. Elsevier/North-Holland Biomedical Press, Amsterdam .
  • Fonnum, F., Storm-Mathisen, J., and Divac, I. (1981a) Biochemical evidence for glutamate as neurotransmitter in the cortico-striatal and cortico-thalamic fibres in rat brain. Neuroscience 6, 863875.
  • Fonnum, F., Søreide, A., Kvale, I., Walker, J., and Walaas, I. (1981b) Glutamate in corticofugal fibres in glutamate as a neurotransmitter in Advances in Biochemical Psychopharmacology, Vol. 27 (DiChiara, G. and Gessa, G. L., eds), pp. 2941. Raven Press, New York .
  • Godukhin, O. V., Zharikova, A. D., and Novoselov, V. I. (1980) The release of labeled L-glutamic acid from rat neostriatum in vivo following stimulation of frontal cortex. Neuroscience 5, 21512154.
  • Graham Aprison, M. H. (1969) Distribution of some enzymes associated with the metabolism of aspartate, glutamate, γ-aminobutyrate and glutamine in cat spinal cord. J. Neurochem. 16, 559566.
  • Haldeman, S. and Mc Lennan, H. (1972) The antagonistic action of glutamic acid diethylester towards amino acid-induced and synaptic excitation of central neurones. Brain Res. 45, 393400.
  • Haldeman, S. and Mc Lennan, H. (1973) The action of two inhibitors of glutamic acid uptake upon amino acid-induced and synaptic excitations of thalamic neurones. Brain Res. 63, 123129.
  • Hamberger, A., Chiang, G. H., Nylén, E. S., Scheff, S. W., and Cotman, C. W. (1979a) Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate. Brain Res. 168, 513530.
  • Hamberger, A., Chiang, G. H., Sandoval, E., and Cotman, C. W. (1979b) Glutamate as a CNS transmitter. II. Regulation of synthesis in the releasable pool. Brain Res. 168, 531541.
  • Hassler, R., Haug, P., Nitsch, C., Kim, J. S., and Paik, K. (1982) Effect of motor and premotor cortex ablation on concentrations of amino acids, monoamines, and acetylcholine and on the ultrastructure in rat striatum. A confirmation of glutamate as the specific cortico-striatal transmitter. J. Neurochem. 38, 10871098.
  • Henn, F. A. and Hamberger, A. (1971) Glial cell function: uptake of transmitter substances. Proc. Natl. Acad. Sci. USA 68, 26862690.
  • Hertz, L., Bock, E., and Schousboe, A. (1979) GFA content, glutamate uptake and activity of glutamate metabolizing enzymes in differentating mouse astrocytes in primary cultures. Dev. Neurosci. 1, 226238.
  • Hokfelt, T. and Ljungdahl, A. (1972) Autoradiographic identification of cerebral and cerebellar cortical neurons accumulating labelled gamma-aminobutyric acid. Exp. Brain Res. 14, 354362.
  • Hudson, D. B., Valcana, T., Bean, G., and Timiras, P. S. (1976) Glutamic acid: a strong candidate as the neurotransmitter of the cerebellar granule cell. Neurochem. Res. 1, 8392.
  • Jasper, H. H. and Koyama, I. (1969) Rate of release of amino acids from the cerebral cortex in the cat as affected by brain-stem and thalamic stimulation. Can. J. Physiol. Pharmacol. 47, 887905.
  • Johnson, J. L. (1972) An analysis of the activities with the inter-conversion of α-ketoglutarate and glutamate: correlations with free glutamate levels in 20 specific regions in the nervous system. Brain Res. 45, 205215.
  • Johnston, G. A. R., Lodge, D., Bornstein, J. C., and Curtis, D. R. (1980) Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurons by the stereoisomers of threo-3--bydroxyaspartate. J. Neurochem. 34, 241243.
  • Kane, E. S. (1979) Central transport and distribution of labelled glutamic and aspartic acids to the cochlear nucleus in cats: an autoradiography study. Neuroscience 4, 729745.
  • Kontro, P., Marnela, K. M., and Oja, S. S. (1980) Free amino acids in the synaptosome and synaptic vesicle fractions of different bovine brain area. Brain Res. 184, 129141.
  • Korf, J. and Venema, K. (1983) Amino acids in the substantia nigra of rats with striatal lesions produced by kainic acid. /. Neurochem. 40, 11711173.
  • Krebs, H. A. (1935) Metabolism of amino acids. IV. Synthesis of glutamine from glutamic acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissue. Biochem. J. 29, 19511969.
  • Kvamme, E. and Olsen, B. E. (1980) Substrate mediated regulation of phosphate-activated glutaminase in nervous tissue. Brain Res. 181, 228233.
  • Lambert, J. D. C., Flatman, J. A., and Engberg, J. (1981) Actions of excitatory amino acids on membrane conductance and potential in motoneurones, in Glutamate as a Neurotransmitter (DiChiara, G. and Gessa, G. L., eds), pp. 205216. Raven Press, New York .
  • Levi, G., Roberts, P. J., and Raiteri, M. (1976) Release and exchange of neurotransmitters in synaptosomes: effects of the ionophore A23187 and of ouabain. Neurochem. Res. 1, 409416.
  • Levi, G., Gordon, R. D., Gallo, V., Wilkin, G. P., and Balazs, R. (1982) Putative acidic amino acid transmitters in the cerebellum. Brain Res. 239, 425445.
  • Logan, W. J. and Snyder, S. H. (1971) Unique high affinity uptake systems for glycine, glutamic and aspartic acids in central nervous tissue of the rat. Nature 234, 297299.
  • Lucas, D. R. and Newhouse, J. P. (1957) The toxic effect of sodium L-glutamate on the inner layers of the retina. Ann. Am. Ophthalmol. 58, 193200.
  • Lund-Karlsen, R. and Fonnum, F. (1976) The toxic effect of sodium glutamate on rat retina: changes in putative transmitters and their corresponding enzymes J. Neurochem. 27, 14371441.
  • Lund-Karlsen, R. and Fonnum, F. (1978) Evidence for glutamate as a neurotransmitter in the corticofugal fibres to the dorsal lateral geniculate body and the superior colliculus in rats. Brain Res. 151, 457467.
  • Machiyama, Y., Balazs, R., Hammond, B. J., Julian, T., and Richer, D. (1970) The metabolism of GABA and glucose in potassium stimulated brain tissue in vitro. Biochem J. 116, 469482.
  • Malthe-Sørenssen, D., Skrede, K. K., and Fonnum, F. (1979) Calcium dependent release of D-[3--H]aspartate evoked by selective electrical stimulation of excitatory afferent fibres to hippocampal pyramidal cells in vitro. Neuroscience 4, 12551263.
  • Malthe-Sørenssen, D., Skrede, K. K., and Fonnum, F. (1980) Release of [3H]-D-aspartate from dorso-lateral septum after electrical stimulation of fimbria in vitro. Neuroscience 5, 127133.
  • Mangan, S. L. and Whittaker, V. P. (1966) The distribution of free amino acids in suhcellular fractions of guinea-pig brain. Biochem. J. 98, 128137.
  • Marc, R. E. and Lam, D. M.W. (1981) Uptake of aspartic and glutamic acid by photoreceptors in goldfish retina. Proc. Natl Acad. Sci. USA 78, 71857189.
  • Mc Bean, G. J. and Roberts, P. J. (1981) Glutamate-preferring receptors regulate the release of D-[3H]aspartate from rat hippocampal slices. Nature 291, 593594.
  • Mc Geer, P. L., Mc Geer, E. G., Scherer, U., and Singh, K. (1977) A glutamergic corticostriatal path Brain Res. 128, 369373.
  • Mc Lennan, H. (1981) On the nature of the receptors for various excitatory amino acids in the mammalian central nervous system. Adv. Biochem. Psychopharmacol. 27, 283262.
  • Meister, A. (1979) Biochemistry of glutamate, glutamine and glutathione, in Advances in Biochemistry and Physiology: Glutamic Acid (Keler Garattini, S., Kane, M. R., Reynolds, W. A., Wurtman, R. J. eds), pp. 6484. Raven Press, New York .
  • Michaelis, E. W., Michaelis, M. L., Stormann, T. M., Chittenden, W. L., and Grubbs, R. D. (1983) Purification and molecular characterization of the brain synaptic membrane glutamatebinding protein. J. Neurochem. 40, 17421753.
  • Minchin, M. C. W. and Beart, P. M. (1974) Compartmentation of amino acid metabolism in the rat dorsal ganglia: a metabolic and autoradiographic study. Brain Res. 83, 437449.
  • Minchin, M. C. W. and Fonnum, F. (1979) The metabolism of GABA and other amino acids in rat substantia nigra slices following lesions of the striato-nigral pathway. J. Neurochem. 32, 203210.
  • Nadler, J. V. and Smith, E. M. (1981) Perforant path lesion depletes glutamate content of fascia dentata synaptosomes. Neurosci. Lett. 3, 275280.
  • Nadler, J. V., White, W. F., Vaca, K. W., Redburn, D. A., and Cotman, C. W. (1977) Characterization of putative amino acid transmitter release from slices of rat dentate gyrus. J. Neurochem. 29, 179290.
  • Nadler, J. V., White, W. F., Vaca, K. W., Perry, B. W., and Cotman, C. W. (1978) Biochemical correlates of transmission mediated by glutamate and aspartate. J. Neurochem. 31, 147155.
  • Naito, S. and Ueda, T. (1983) Adenosine triphosphate-dependent uptake of glutamate into protein 1--associated vesicles. J. Biol. Chem. 258, 696699.
  • Nitsch, C., Kim, J.-K., Shimada, Y., and Okada, Y. (1979) Effects of hippocampus extirpation in the rat on glutamate levels in the target structures of hippocampal efferents. Neurosci. Lett. 11, 295299.
  • Norenberg, M. D. and Martinez-Hernandez, A. (1979) Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res. 161, 303310.
  • Norris, P. J., Smith, C. C. T., de Belleroche, J., Bradford, H. F., Mantle, P. G., Thomas, A. J., and Penny, R. H. C. (1980) Actions of tremorgenic fungal toxins on neurotransmitter release. J. Neurochem. 34, 3343.
  • Oldendorf, W. H. (1971) Brain uptake of radiolabelled amino acids, amines, and hexoses after arterial injection. Am. J. Physiol. 221, 16291639.
  • Oldendorf, W. H. and Szabo, J. (1976) Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am. J. Physiol. 230, 9498.
  • Olney, J. W., Rhee, V., and Ho, O. L. (1974) Kainic acid: A powerful neurotoxic analogue of glutamate. Brain Res. 77, 507512.
  • Ottersen, O. P. and Storm-Mathisen, J. (1983) Neurons containing or accumulating transmitter amino acids, in Handbook of Chemical Neuroanatomy, Vol 2 (Bjørklund, A. and Hokfelt, T., eds) (in press).
  • Potashner, S. J. (1978) The spontaneous and electrically evoked release from slices of guinea-pig cerebral cortex of endogenous amino acids labelled via metabolism of D-[U-14] glucose. J. Neurochem. 31, 177186.
  • Pratt, O. E. (1976) The transport of metabolizable substances into the living brain. Adv. Exp. Biol. Med. 69, 5575.
  • Raiteri, M. and Levi, G. (1973) Depletion of synaptosomal neurotransmitter pool by sudden cooling. Nature 243, 180182.
  • Rassin, D. L. (1972) Amino acids as putative transmitters: failure to bind to synaptic vesicles of guinea-pig cerebral cortex. J. Neurochem. 19, 139148.
  • Rea, M. A., Mc Bride, W. J., and Rhode, B. (1980) Regional and synaptosomal levels of amino acid neurotransmitters in 3--acetylpyridine deafferented rat cerebellum. J. Neurochem. 34, 11061108.
  • Reijnierse, G. L. A., Veldstra, H., and van den Berg, C. J. (1975) Subcellular localization of 7--aminobutyrate transaminase and glutamate dehydrogenase in adult rat brain. Biochem. J. 152, 469475.
  • Reubi, J. C. (1980) Comparative study of the release of glutamate and GABA, newly synthesized from glutamine in various regions of the central nervous system. Neuroscience 5, 21452150.
  • Reubi, J. C. and Cuenod, M. (1979) Glutamate release in vitro from cortico-striatal terminals. Brain Res. 176, 185188.
  • Reubi, J. C., Toggenburger, G., and Cuenod, M. (1980) Asparagine as precursor for transmitter aspartate in corticostriatal fibres. J. Neurochem. 35, 10151017.
  • Roberts, E. and Frankel, D. (1950) 7--Aminobutyric acid in brain: its formation from glutamic acid. J. Biol. Chem. 187, 5563.
  • Roberts, P. J. and Watkins, J. C. (1975) Structural requirements for the inhibition of L-glutamate uptake by glia and nerve endings. Brain Res. 85, 120125.
  • Roberts, P. J., Storm-Mathisen, J., and Johnston, G. A. R. (1981) Glutamate Transmitter in the Central Nervous System. John Wiley & Sons, Chichester .
  • Rohde, B. H., Rea, M. A., Simon, J. R., and Mc Bride, W. J. (1979) Effects of X-irradiation-induced loss of cerebellar granule cells on synaptosomal levels and the high affinity uptake of amino acids. J. Neurochem. 32, 14311435.
  • Rowlands, G. J. and Roberts, P. J. (1980) Specific calcium-dependent release of endogenous glutamate from rat striatum is reduced by destruction of the cortico-striatal tract. Exp. Brain Res. 39, 239240.
  • Rustioni, A. and Cuenod, M. (1982) Selective retrograde transport of D-aspartate in spinal interneurons and cortical neurons of rats. Brain Res. 236, 143155.
  • Rustioni, A., Spreafico, R., Cheema, S., and Cuenod, M. (1982) Selective retrograde labelling of somatosensory cortical neurons after 3H-D-aspartate injections in the ventrobasal complex of rats and cats. Neuroscience (Suppl.) 7, S183.
  • Sandoval, M. E. and Cotman, C. W. (1978) Evalution of glutamate as a neurotransmitter of cerebellar fibres. Neuroscience 3, 199206.
  • Schon, F. and Kelly, J. S. (1974) Autoradiographic localization of [3H]-GABA and [3H]-glutamate over satellite glial cells. Brain Res. 66, 275288.
  • Sellström, A. and Hamberger, A. (1977) Potassium-stimulated γ-aminobutyric acid release from neurons and glia. Brain Res. 119, 189198.
  • Shank, R. P. and Campbell Lem. (1982) Glutamine and alphaketoglutarate uptake and metabolism by nerve terminal enriched material from mouse cerebellum. Neurochem. Res. 7, 601616.
  • Shank, R. P. and Campbell Lem. (1983) Amino acid uptake, content and metabolism by neuronal and glial enriched cellular fractions from mouse cerebellum. J. Neurosci (in press).
  • Sharif, N. A. and Roberts, P. J. (1981) L-Aspartate binding sites in rat cerebellum: a comparison of the binding of L-[3H]aspartate and L-[3H]glutamate to synaptic membranes. Brain Res. 211, 293303.
  • Skrede, K. K. and Malthe-Sørenssen, D. (1981) Differential release of D-[3H]aspartate and [14C]-γ-aminobutyric acid following activation of commissural fibres in a longitudinal slice preparation of guinea-pig hippocampus. Neurosci. Lett. 21, 7176.
  • Smith, C. C. T., Bradford, H. F., Thompson, E. J., and MacDermot, J. (1980) Actions of β-bungarotoxin on amino acid transmitter release. J. Neurochem. 34, 487494.
  • Søreide, A. and Fonnum, F. (1980) High affinity uptake of D-[3H]aspartate in the barrel subfield of the mouse somatic sensory cortex. Brain Res. 201, 727730.
  • Spencer, H. J. (1976) Antagonism of cortical excitation of striatal neurons by glutamic acid diethylester: evidence for glutamic acid as an excitatory transmitter in the rat striatum. Brain Res. 102, 91101.
  • Stallcup, W. B., Bulloch, K., and Baetge, E. E. (1979) Coupled transport of glutamate and sodium in cerebellar nerve cell line. J. Neurochem. 32, 5765.
  • Stone, T. W. (1979) Amino acids as neurotransmitters of corti-cofugal neurons in the rat: a comparison of glutamate and aspartate. Br. J. Pharmacol. 67, 545551.
  • Storm-Mathisen, J. (1977) Glutamic acid and excitatory nerve endings: reduction of glutamic acid uptake after axotomy. Brain Res. 120, 379386.
  • Storm-Mathisen, J. and Iversen, L. L. (1979) Uptake of [3H]-glutamic acid in excitatory nerve endings. Light and electron-microscopic observations in the hippocampal formation of the rat. Neuroscience 4, 12371253.
  • Storm-Mathisen, J. and Woxen-Opsahl, M. (1978) Aspartate and/ or glutamate may be transmitters in hippocampal efferents to septum and hypothalamus. Neurosci. Lett. 9, 6570.
  • Storm-Mathisen, J., Leknes, A. K., Bore, A. T., Vaaland, J. L., Edminson, P., Haug, F. M.-S., and Ottersen, O. P. (1983) Glutamate and GABA: first visualization in neurones by immunocytochemistry. Nature 301, 517520.
  • Streit, P. (1980) Selective retrograde labeling indicating the trans mitter of neuronal pathways. J. Comp. Neurol. 191, 429463.
  • Talman, W. T., Perrone, M. H., and Reis, D. J. (1980) Evidence of glutamate as a neurotransmitter of baroreceptor afferent nerve fibres. Science 209, 813815.
  • Thangnipon, W., Taxt, T., Brodal, P., and Storm-Mathisen, J. (1983) The corticopontine projection: axotomy-induced loss of high affinity L-glutamate and D-aspartate uptake, but not of gamma-aminobutyrate uptake, glutamate decarboxylase or choline acetyltransferase, in the pontine nuclei. Neuroscience 8, 449457.
  • Thanki, C. M., Sugden, D., Thomas, N. J., and Bradford, H. F. (1983) In vivo release from cerebral cortex of [14C]glutamate synthesized from [U-14C]glutamine. J. Neurochem. 41, 611617.
  • Toggenburger, G., Felix, D., Cuenod, M., and Henke, H. (1982) In vitro release of endogenous beta-alanine, GABA and glutamate, and electrophysiological effect of beta-alanine in pigeon optic tectum. J. Neurochem. 39, 176183.
  • Usherwood, P. N. R. (1981) Glutamate synapses and receptors in insect muscle, in Glutamate as a Neurotransmitter (Di-Chiara, G. and Gessal, G. L., eds), pp 183192. Raven Press, New York .
  • van den Berg, C. J. (1973) A model of compartrnentation in mouse brain based on glucose and acetate metabolism, in Metabolic Compartmentation in the Brain (Balazs, R. and Cremer, J. E., eds), pp. 137166. Macmillan, New York .
  • van den Berg, C. J., Matheson, D. F., Ronda, G., Reijnierse, G. L. A., Blokhuis, G. G. D., Kroon, M. C., Clarke, D. D., and Garfinkel, D. (1975) A model of glutamate metabolism in brain: a biochemical analysis of a heterogenous structure, in Metabolic Compartmentation and Neurotransmission (Berl, S., Clarke, D. D., and Schneider, D., eds), pp. 709723. Plenum Press, New York .
  • Vincent, S. R. and Mc Geer, E. G. (1980) A comparison of sodium dependent glutamate binding with high affinity glutamate uptake in rat striatum. Brain Res. 184, 99105.
  • Walaas, I. (1981) Biochemical evidence for overlapping neocor-tical and allocortical glutamate projections to the nucleus accumbens and rostral caudatoputamen in the rat brain. Neuroscience 6, 399406.
  • Walaas, I. and Fonnum, F. (1979) The effects of surgical and chemical lesions on neurotransmitter candidates in the nucleus accumbens of the rat. Neuroscience 4, 209216.
  • Walaas, I. and Fonnum, F. (1980) Biochemical evidence for glutamate as a transmitter in hippocampal efferents to the basal forebrain and hypothalamus in rat brain. Neuroscience 5, 16911698.
  • Walker, J. and Fonnum, F. (1983) Regional cortical glutamergic and aspartergic projections to the amygdala and thalamus of the rat. Brain Res. 267, 371374.
  • Waniewski, R. A. and Martin, D. L. (1983) Selective inhibition of glial versus neuronal uptake of L-glutamic acid by SITS. Brain Res. 268, 390394.
  • Ward, H. W., Thanki, C. M., Peterson, D. W., and Bradford, H. F. (1982) Brain glutaminase activity in relation to transmitter glutamate biosynthesis. Biochem. Soc. Trans. 10, 369370.
  • Ward, H. W., Thanki, C. M., and Bradford, H. F. (1983) Glutamine and glucose as precursors of transmitter amino acids: ex vivo studies. J. Neurochem. 40, 855860.
  • Watkins, J. C. (1981) Pharmacology of excitatory amino acid receptors, in Glutamate: Transmitter in the Central Nervous System (Roberts, P. J., Storm-Mathisen, J., and Johnston, G. A. R., eds), pp. 124. John Wiley & Sons, Chichester .
  • Weil-Malherbe, H. (1950) Significance of glutamic acid for the metabolism of nervous tissue. Physiol. Rev. 30, 549568.
  • Wenthold, R. J. (1978) Glutamic acid and aspartic acid in subdivisions of the cochlear nucleus after auditory nerve lesion. Brain Res. 143, 544548.
  • Wenthold, R. J. (1979) Release of endogenous glutamic acid, aspartic acid and GABA from cochlear nucleus slices. Brain Res. 162, 338343.
  • Wenthold, R. J. (1980) Glutaminase and aspartate amino trans-ferase decrease in cochlear nucleus after lesion of the auditory. Brain Res. 190, 283297.
  • Wheeler, D. D. and Hollingsworth, R. G. (1978) A model of high affinity glutamic acid transport by cortical synaptosomes from the Long-Evans rat. J. Neurochem. 30, 13111319.
  • Wieraszko, A. and Lynch, G. (1979) Stimulation dependent release of possible transmitter substances from hippocampal slices studied with localized perfusion. Brain Res. 160, 372376.
  • Wiklund, L., Toggenburger, G., and Cuenod, M. (1982) Aspartate: possible neurotransmitter in cerebellar climbing fibers. Science 216, 7880.
  • Wilkins, G. P., Garthwaite, J., and Balazs, R. (1982) Putative amino acid transmitters in the cerebellum. II. Electron microscopic localization of transport sites. Brain Res. 244, 6980.
  • Yoneda, Y., Roberts, E., and Dietz Young, A. B., Oster-Granite, M. L., Herndon, R. M., and Snyder, S. H. (1974) Glutamic acid: selective depletion by viral induced granule cell loss in hamster cerebellum. Brain Res. 73, 113.
  • Young, A. B., Bromberg, M. B., and Penny, J. B. (1981) Decreased glutamate in subcortical areas deafferented by sensorimotor cortex ablation in the cat. J. Neurosci. 1, 241249.