Receptor Activation and Inositol Lipid Hydrolysis in Neural Tissues

Authors

  • Stephen K. Fisher,

    1. Neuroscience Laboratory and Departments of Pharmacology, University of Michigan, Ann Arbor, Michigan, U.S.A.
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  • Bernard W. Agranoff

    Corresponding author
    1. Neuroscience Laboratory and Departments of Biological Chemistry, and Psychiatry, University of Michigan, Ann Arbor, Michigan, U.S.A.
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Address correspondence and reprint requests to Dr. B. W. Agranoff at Neuroscience Laboratory Building, University of Michigan, 1103 East Huron, Ann Arbor, MI 48104–1687, U.S.A.

Abbreviations used:
ACh

acetylcholine

ACTH

corticotropin (1–24)tetracosapeptide

APB

dl-2-amino-4-phosphobutyric acid

APV

dl-2-amino-5-phosphonovalerate

CDP-DG

cytidine di-phosphodiacylglycerol

DG

1,2-diacyl-sn-glycerol

GAP

growth-associated protein

G-protein

guanine nucleotide binding protein

5-HT

5-hydroxytryptamine

IP1

d-myo-inositol 1-phosphate

IP2

d-myo-inositol 1,4-bisphosphate

IP3

d-myo-inositol 1,4,5-tris-phosphate

IP4

D-myo-inositol 1,3,4,5-tetrakisphosphate

mAChR

muscarinic acetylcholine receptor

NMDA

N-methyl d-aspartate

PA

phosphatidic acid

PI

phosphatidylinositol

PIP

phosphatidylinositol 4-phosphate

PIP2

phosphatidylinositol 4,5-bisphosphate

PK-C

protein kinase C

PMA

4β-phorbol 12-myristate 13-acetate

TRH

thyrotropin-releasing hormone. The 1,2 cyclic derivatives of IP., IP2, and IP3, in which there is a phosphodiester bridge between the D-1 and D-2 positions of myo-inositol, are designated by the prefix “c.” Thus, for example, (c1,2)-IP1 is d-1,2 (cyclic) myo-inosi-tol phosphate. The abbreviations used for inositol lipids and inositol phosphates are those recommended at the Chilton Conference on Inositol and Phosphoinositides (Dallas, TX, January 1984) (see Agranoff et al., 1985). The standard IUPAC-IUB abbreviations for phosphatidylinositol, phosphatidylinositol 4-phosphate, and phosphatidylinositol 4,5-bisphosphate are PtdIns, PtdIns 4-P, and Pt-dlns 4,5-Pz

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