Reduced Phosphoinositide Concentrations in Anterior Temporal Cortex of Alzheimer-Diseased Brains


Address correspondence and reprint requests to Prof. J. N. Hawthorne at Department of Biochemistry, University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH. U.K.


Abstract: Samples of brain anterior temporal cortex from 17 patients with Alzheimer's disease and 18 age-matched controls have been analysed for myo-inositol and the three phosphoinositides. There was significantly less phosphati-dylinositol in the Alzheimer samples (1.36 μmol/g wet weight) than in the controls (2.28 μmol/g). The concentrations of phosphatidylinositol 4-phosphate and phosphati-dylinositol 4,5-bisphosphate were also lower in Alzheimer cortex, but differences from the control group were not statistically significant. Free myo-inositol concentrations were 5.11 μmol/g (Alzheimer) and 4.44 μmol/g (control) and again the difference was not significant. The lack of phosphoinositides in Alzheimer temporal cortex may impair receptor function.