This work was presented in part at the 6th General Meeting of the European Society for Neurochemistry, held September 1–6, 1986, in Prague, Czechoslovakia, and an abstract has been published.
Triiodothyronine-Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 48, Issue 4, pages 1053–1059, April 1987
How to Cite
Cestelli, A., Di Liegro, I., Castiglia, D., Gristina, R., Ferraro, D., Salemi, G. and Savettieri, G. (1987), Triiodothyronine-Induced Shortening of Chromatin Repeat Length in Neurons Cultured in a Chemically Denned Medium. Journal of Neurochemistry, 48: 1053–1059. doi: 10.1111/j.1471-4159.1987.tb05626.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received July 4, 1986; revised September 26, 1986; accepted September 26, 1986
- Neuronal terminal differentiation;
- Chromatin structure;
- Chemically denned medium)
Abstract: At the time of terminal differentiation, mammalian cortical neurons undergo a dramatic change in the structural organization of their chromatin: the nucleosomal repeat length shortens from ∼200 base pairs in fetuses to a value of 165 base pairs after birth. These events occur several days after the end of neuronal proliferation. Previously, we reported that rat cortical neurons cultured in a very selective synthetic medium were not yet programmed to these events at the end of mitotic cycles. Herein, we report that addition of triiodothyronine to neuronal cultures induces a shortening of the chromatin repeat length comparable to the natural one.