Effect of High Doses of Dietary Vitamin E on the Concentrations of Vitamin E in Several Brain Regions, Plasma, Liver, and Adipose Tissue of Rats
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 51, Issue 2, pages 621–623, August 1988
How to Cite
Vatassery, G. T., Brin, M. F., Fahn, S., Kayden, H. J. and Traber, M. G. (1988), Effect of High Doses of Dietary Vitamin E on the Concentrations of Vitamin E in Several Brain Regions, Plasma, Liver, and Adipose Tissue of Rats. Journal of Neurochemistry, 51: 621–623. doi: 10.1111/j.1471-4159.1988.tb01083.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received November 23, 1987; final revised manuscript received March 8, 1988; accepted March 8, 1988.
- Vitamin E;
- Megavitamin E;
Abstract: The object of this study was to assess the influence of high levels of dietary vitamin E on vitamin E concentrations in specific areas of the brain. Four-week-old male rats were fed vitamin E-deficient, control, and high-vitamin E (1,000 IU/kg) diets for 4 months. Concentrations of α-tocopherol in serum, adipose tissue, liver, cerebrum, cerebellum, and striatum were determined by liquid chromatography with fluorescence detection. In the high-vitamin E group, α-tocopherol concentrations in cerebrum, cerebellum, and striatum increased uniformly to 1.4-fold of values in controls; serum, adipose tissue, and liver attained even higher concentrations: 2.2-, 2.2-, and 4.6-fold, respectively, of control values. As observed before, brain levels of α-tocopherol were somewhat resistant to vitamin E deficiency, in contrast to the peripheral tissues.