Down's Syndrome Individuals Begin Life with Normal Levels of Brain Cholinergic Markers
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 52, Issue 4, pages 1183–1187, April 1989
How to Cite
Kish, S., Karlinsky, H., Becker, L., Gilbert, J., Rebbetoy, M., Chang, L.-J., DiStefano, L. and Hornykiewicz, O. (1989), Down's Syndrome Individuals Begin Life with Normal Levels of Brain Cholinergic Markers. Journal of Neurochemistry, 52: 1183–1187. doi: 10.1111/j.1471-4159.1989.tb01864.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received May 20, 1988; final revised manuscript received September 21, 1988; accepted September 25, 1988.
- Down's syndrome;
- Choline acetyltransferase;
- Alzheimer's disease
Abstract We measured the activities of the cholinergic marker enzymes choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) in autopsied brains of seven infants (age range 3 months to 1 year) with Down's syndrome (DS), a disorder in which virtually all individuals will develop by middle age the neuropathological changes of Alzheimer's disease accompanied by a marked brain cholinergic reduction. When compared with age-matched controls cholinergic enzyme activity was normal in all brain regions of the individuals with infant DS with the exception of above-normal activity in the putamen (ChAT) and the occipital cortex (AChE). Our neurochemical observations suggest that DS individuals begin life with a normal complement of brain cholinergic neurons. This opens the possibility of early therapeutic intervention to prevent the development of brain cholinergic changes in patients with DS.