Dr. P. Cabré is Department of Anaesthesiology, Hospital San Rafel, Barcelona, Spain.
Relationship Between Serotoninergic Measures in Blood and Cerebrospinal Fluid Simultaneously Obtained in Humans
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 54, Issue 3, pages 783–786, March 1990
How to Cite
Sarrias, M. J., Cabré, P., Martínez, E. and Artigas, F. (1990), Relationship Between Serotoninergic Measures in Blood and Cerebrospinal Fluid Simultaneously Obtained in Humans. Journal of Neurochemistry, 54: 783–786. doi: 10.1111/j.1471-4159.1990.tb02319.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received March 14, 1989; revised manuscript received July 2, 1989; accepted July 19, 1989.
- Cerebrospinal fluid;
- Monoamine metabolites
Abstract: The relationships between the concentration of serotonin (5-HT) and related metabolites in human blood and CSF have been studies. Plasma tryptophan (TP), 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), and indoleacetic acid (IAA), whole-blood 5-HT, and CSF TP, 5-HT, 5-HIAA, IAA, homovanillic acid, and 3-methoxy-4-hydroxyphenylethylene glycol were determined in 35 unmedicated outpatients who underwent minor surgical operations and had no history of psychiatric or neurological illnesses. Significant correlations were found between the serotoninergic parameters analyzed in blood and CSF. Plasma free 5-HT correlated significantly with CSF 5-HT (r= 0.411, p < 0.02), and plasma 5-HIAA correlated with the CSF 5-HIAA/5-HT ratio (r= 0.508, p < 0.004). The concentration of 5-HIAA in CSF correlated with the plasma 5-HIAA/5-HT ratio (r= 0.405, p < 0.026) (which can be taken as an index of monoamine oxidase type A activity in peripheral tissues) and with the platelet 5-HT/plasma 5-HT ratio (r= 0.375, p < 0.05). The concentrations of IAA in CSF and plasma were strongly correlated (r= 0.899, p < 0.001). The significance of these results and their relationship to the use of “in vivo”measures of 5-HT and related metabolites in plasma and platelets as an index of serotoninergic function in affective disorders are discussed.