Striatal Restricted Adenosine A2 Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry Study
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 57, Issue 3, pages 1062–1067, September 1991
How to Cite
Schiffmann, S. N., Jacobs, O. and Vanderhaeghen, J.-J. (1991), Striatal Restricted Adenosine A2 Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry Study. Journal of Neurochemistry, 57: 1062–1067. doi: 10.1111/j.1471-4159.1991.tb08257.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received December 17, 1990; revised manuscript received February 11, 1991; accepted February 21, 1991.
- Adenosine A2 receptor;
- Substance P;
RDC8 has been recently cloned and characterized as an adenosine A2 receptor. This receptor is expressed exclusively by medium-sized neurons of the striatum as demonstrated by in situ hybridization. We have now studied the relationship of this receptor with three major components of the rat caudate-putamen: enkephalin, substance P, and choline acetyltransferase. Our results demonstrate that the adenosine A2 receptor is expressed exclusively by the enkephalinergic striatal subpopulation but not by the substance P-containing or cholinergic neurons.