Get access

Striatal Restricted Adenosine A2 Receptor (RDC8) Is Expressed by Enkephalin but Not by Substance P Neurons: An In Situ Hybridization Histochemistry Study

Authors

  • Serge N. Schiffmann,

    Corresponding author
    1. Laboratory of Neuropathology and Neuropeptide Research, Erasme and Brugmann Academic Hospitals, Faculty of Medicine, Universite Libre de Bruxelles, Bruxelles, Belgium
      Address correspondence and reprint requests to Dr. S. N. Schiffmann at Laboratory of Neuropathology and Neuropeptides Research, Universite Libre de Bruxelles, Campus Erasme, CP 601, 808 route de Lennik, 1070 Brussels, Belgium.
    Search for more papers by this author
  • Olivier Jacobs,

    1. Laboratory of Neuropathology and Neuropeptide Research, Erasme and Brugmann Academic Hospitals, Faculty of Medicine, Universite Libre de Bruxelles, Bruxelles, Belgium
    Search for more papers by this author
  • Jean-Jacques Vanderhaeghen

    1. Laboratory of Neuropathology and Neuropeptide Research, Erasme and Brugmann Academic Hospitals, Faculty of Medicine, Universite Libre de Bruxelles, Bruxelles, Belgium
    Search for more papers by this author

Address correspondence and reprint requests to Dr. S. N. Schiffmann at Laboratory of Neuropathology and Neuropeptides Research, Universite Libre de Bruxelles, Campus Erasme, CP 601, 808 route de Lennik, 1070 Brussels, Belgium.

Abstract

RDC8 has been recently cloned and characterized as an adenosine A2 receptor. This receptor is expressed exclusively by medium-sized neurons of the striatum as demonstrated by in situ hybridization. We have now studied the relationship of this receptor with three major components of the rat caudate-putamen: enkephalin, substance P, and choline acetyltransferase. Our results demonstrate that the adenosine A2 receptor is expressed exclusively by the enkephalinergic striatal subpopulation but not by the substance P-containing or cholinergic neurons.

Get access to the full text of this article

Ancillary