• c-fos;
  • y-Hexachlorocyclohexane;
  • CNS;
  • γ-Aminobutyric acidA-receptor antagonist;
  • Convulsion

Abstract: The induction of protooncogene c-fos in the CNS after administration of several convulsants has been studied. The organochlorine insecticide γ-hexachlorocyclohexane (γ-HCH, lindane) has been shown to induce c-fos expression in different brain areas. Pentylenetetrazole and picrotoxin, a known γ-aminobutyric acid-receptor antagonist, have also been considered. The administration of two nonconvulsant isomers of γ-HCH, α-HCH, and δ-HCH, before the mentioned toxicants, affects the protooncogene expression in different ways. The differential pattern of expression displayed by c-fos after these treatments suggests the presence of diverse mechanisms of action for the compounds studied.