c-fos Expression as a Model for Studying the Action of Hexachlorocyclohexane Isomers in the CNS
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 58, Issue 3, pages 862–869, March 1992
How to Cite
Vendrell, M., Tusell, J. M. and Serratosa, J. (1992), c-fos Expression as a Model for Studying the Action of Hexachlorocyclohexane Isomers in the CNS. Journal of Neurochemistry, 58: 862–869. doi: 10.1111/j.1471-4159.1992.tb09336.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received April 30, 1991; revised manuscript received July 4, 1991; accepted July 25, 1991.
- γ-Aminobutyric acidA-receptor antagonist;
Abstract: The induction of protooncogene c-fos in the CNS after administration of several convulsants has been studied. The organochlorine insecticide γ-hexachlorocyclohexane (γ-HCH, lindane) has been shown to induce c-fos expression in different brain areas. Pentylenetetrazole and picrotoxin, a known γ-aminobutyric acid-receptor antagonist, have also been considered. The administration of two nonconvulsant isomers of γ-HCH, α-HCH, and δ-HCH, before the mentioned toxicants, affects the protooncogene expression in different ways. The differential pattern of expression displayed by c-fos after these treatments suggests the presence of diverse mechanisms of action for the compounds studied.