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  • Alderson R. F., Alterman A. L., Barde Y. A., and Lindsay R. M. (1990) Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron 5, 297306.
  • Ayer-LeLievre C., Olson L., Ebendahl T., Seiger A., and Persson H. (1988) Expression of the beta-nerve growth factor gene in hippocampal neurons. Science 240, 13391341.
  • Barde Y.-A. (1989) Trophic factors and neuronal survival. Neuron 2, 15251534.
  • Berg M. M., Sternberg D. W., Parada L. F., and Chao M. V. (1992) K-252a inhibits nerve growth factor-induced trk proto-oncogene tyrosine phosphorylation and kinase activity. J. Biol. Chem. 267, 1316.
  • Berkemeier L. R., Winslow J. W., Kaplan D. R., Nikolics K., Goeddel D. V., and Rosenthal A. (1991) Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron 7, 857866.
  • Borasio G. D. (1990) Differential effects of the protein kinase inhibitor K-252a on the in vitro survival of chick embryonic neurons. Neurosci. Lett. 108, 207212.
  • Bothwell M. (1991) Keeping track of neurotrophin receptors. Cell 65, 915918.
  • Carpenter G. and Cohen S. (1990) Epidermal growth factor. J. Biol. Chem. 265, 77097712.
  • Chao M. V., Bothwell M. A., Ross H., Koprowski A. A., Lanahan C. R., Buck C. R., and Sehgal A. (1986) Gene transfer and molecular cloning of the human NGF receptor. Science 232, 518521.
  • Cordon-Cardo C., Tapley P., Jing S., Nandure V., O'Rourke E., Lamballe F., Kovary K., Klein R., Jones K. R., Reichardt L. F., and Barbacid M. (1991) The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell 66, 173183.
  • Davis P. D., Hill C. H., Keech E., Lawton G., Nixon J. S., Sedgwick A. D., Wadsworth J., Westmacott D., and Wilkinson S. E. (1989) Potent selective inhibitors of protein kinase C. FEBS Lett. 259, 6163.
  • Doherty P. and Walsh F. S. (1989) K-252a specifically inhibits survival and morphological differentiation of NGF-dependent neurons in primary cultures of human dorsal root ganglia. Neurosci. Lett. 96, 16.
  • Ehrlich Y. H., Davis T. B., Bock E., Kornecki E., and Lenox R. H. (1986) Ecto-protein kinase activity on the external surface of neural cells. Nature 320, 6770.
  • Ernfors P., Ibanez C. F., Ebendal T., Olson L., and Persson H. (1990) Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographic expression in the brain. Proc. Natl. Acad. Sci. USA 87, 54545458.
  • Fischer W., Wictorin K., Bjorklund A., Williams L. R., Varon S., and Gage F. H. (1987) Amelioration of cholinergic neurons atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature 329, 6568.
  • Greene L. A. (1984) The importance of both early and delayed responses in the biological actions of nerve growth factor. Trends Neurosci. 7, 9194.
  • Greene L. A. and Shooter E. M. (1980) The nerve growth factor: biochemistry, synthesis, and mechanism of action. Annu. Rev. Neurosci. 3, 353402.
  • Gross J. L., Herblin W. F., Do U. H., Pounds J. S., Buenaga L. J., and Stephens L. E. (1990) Characterization of specific [3H]-dimethylstaurosporine binding to protein kinase C. Biochem. Pharmacol. 40, 343350.
  • Hallbook F., Ibanez C. F., and Persson H. (1991) Evolutionary studies on the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron 6, 845858.
  • Hashimoto S. (1988) K-252a, a potent protein kinase inhibitor blocks nerve growth factor-induced neurite outgrowth and changes in the phosphorylation of proteins in PC12h cells. J. Cell Biol. 107, 15311539.
  • Hashimoto S. and Hagino A. (1989) Blockage of nerve growth factor action in PC12h cells by staurosporine, a potent protein kinase inhibitor. J. Neurochem. 53, 16751685.
  • Hefti F. (1986) Nerve growth factor (NGF) promotes survival of septal cholinergic neurons after fimbrial transections. J. Neurosci. 6, 21552162.
  • Hefti F. (1992) Growth factors and neurodegeneration, in Neurodegenerative Diseases (CalneD.), Saunders, Philadelphia (in press).
  • Hefti F. and Schneider L. S. (1989) Rationale for the planned clinical trials with nerve growth factor in Alzheimer's disease. Psychiatr. Dev. 4, 297315.
  • Hefti F., Hartikka J., and Knüsel B. (1989) Function of neurotrophic factors in the adult and aging brain and their possible use in the treatment of neurodegenerative diseases. Neurobiol. Aging 10, 515533.
  • Hempstead B. L., Martin-Zanca D., Kaplan D. R., Parada L. F., and Chao M. V. (1991) High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature 344, 339341.
  • Herbert J. M., Seban E., and Maffrand J. P. (1990) Characterization of specific binding sites for [3H]staurosporine on various protein kinases. Biochem. Biophys. Res. Commun. 171, 189195.
  • Hofer M., Pagliusi S. R., Hohn A., Leibrock J., and Barde Y. A. (1990) Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J. 9, 24592464.
  • Hohn A., Leibrock J., Bailey K., and Barde Y. A. (1990) Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344, 339341.
  • Hyman C., Hofer M., Barde Y. A., Juhasz M., Yancopoulos G. D., Squinto S. P., and Lindsay R. M. (1991) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 350, 230233.
  • Isackson P. J., Towner M. D., and Huntsman M. M. (1991) Comparison of mammalian, chicken, and Xenopus brain-derived neurotrophic factor coding sequences. FEBS Lett. 285, 260264.
  • Jones K. R. and Reichardt L. F. (1990) Molecular cloning of a human gene that is a member of the nerve growth factor family. Proc. Natl. Acad. Sci. USA 87, 80608064.
  • Kaplan D. R., Hempstead B. L., Martin-Zanca D., Chao M. V., and Parada L. F. (1991a) The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science 252, 554558.
  • Kaplan D. R., Martin-Zanca D., and Parada L. F. (1991b) Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350, 158160.
  • Kase H., Iwahishi K., and Matsuda Y. (1986) K-252a, a potent inhibitor of protein kinase C from microbial origin. J. Antibiot. 39, 10591065.
  • Kase H., Iwahashi K., Nakanishi S., Matsuda Y., Yamada K., Takahashi M., Murakata C., Sato A., and Kaneko M. (1987) K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochem. Biophys. Res. Commun. 142, 436440.
  • Klein R., Parada L. F., Coulier F., and Barbacid M. (1989) trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development. EMBO J. 8, 37013709.
  • Klein R., Martin-Zanca D., Barbacid M., and Parada L. F. (1990) Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system. Development 109, 845850.
  • Klein R., Jing S., Nanduri V., O'Rourke E., and Barbacid M. (1991a) The trk proto-oncogene encodes a receptor for nerve growth factor. Cell 65, 189197.
  • Klein R., Nanduri V., Jing S., Lamballe F., Tapley P., Bryant S., Cordon-Cardo C., Jones K. R., Reichardt L. F., and Barbacid M. (1991b) The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell 66, 395404.
  • Knüsel B. and Hefti F. (1991) K-252b is a selective and nontoxic inhibitor of nerve growth factor action on cultured brain neurons. J. Neurochem. 57, 955962.
  • Knüsel B., Winslow J. W., Rosenthal A., Burton L. E., Seid D. P., Nikolics K., and Hefti F. (1991) Promotion of central cholinergic and dopaminergic neuron differentiation by brain-derived neurotrophic factor but not neurotrophin-3. Proc. Natl. Acad. Sci. USA 88, 961965.
  • Knüsel B., Kaplan D. R., Winslow J. W., Rosenthal A., Burton L. E., Beck K. D., Rabin S., Nikolics K., and Hefti F. (1992) K-252b selectively potentiates cellular actions and trk tyrosine phosphorylation mediated by neurotrophin-3. J. Neurochem. 59, 715722.
  • Koizumi S., Contreras M. L., Matsuda Y., Hama T., Lazarovici P., and Guroff G. (1988) K-252a: a specific inhibitor of the action of nerve growth factor on PC12 cells. J. Neurosci. 8, 715721.
  • Koliatsos V. E., Clatterbuck R. E., Nauta H. J. W., Knüsel B., Burton L. E., Hefti F., Mobley W. C., and Price D. L. (1991) Human nerve growth factor prevents degeneration of basal forebrain cholinergic neurons in primates. Ann. Neurol. 30, 831840.
  • Kuo J. F., Shoji M., Kiss Z., Girard P. R., Deli E., Oishi K., and Vogler W. R. (1989) Protein kinase C in cell growth and differentiation. Adv. Exp. Med. Biol. 255, 820.
  • Lamballe F., Klein R., and Barbacid M. (1991) TrkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell 66, 967979.
  • Lapchak P. A., Araujo D. M., and Hefti F. (1991) Neurotrophins in the central nervous system. Rev. Neurosci. 3, 111.
  • Lazarovici P., Levi B. Z., Lelkes P. I., Koizumi S., Fujita K., Matsuda Y., Ozato K., and Guroff G. (1989) K-252a inhibits the increase in c-fos transcription and the increase in intracellular calcium produced by nerve growth factor in PC12 cells. J. Neurosci. Res. 23, 18.
  • Leibrock J., Lottspeich F., Hohn A., Hofer M., Hengerer B., Masiakowski P., Thoenen H., and Barde Y. A. (1989) Molecular cloning and expression of brain-derived neurotrophic factor. Nature 341, 149152.
  • Levi-Montalcini R. (1982) Developmental neurobiology and the natural history of nerve growth factor. Annu. Rev. Neurosci. 5, 341362.
  • Maher P. A. (1989) Role of protein tyrosine phosphorylation in the NGF response. J. Neurosci. Res. 24, 2937.
  • Maisonpierre P. C., Belluscio L., Squinto S., Ip N. Y., Furth M. E., Lindsay R. M., and Yancopoulos G. D. (1990) Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science 247, 14461451.
  • Martin-Zanca D., Oskam R., Mitra G., Copeland T., and Barbacid M. (1989) Molecular and biochemical characterization of the human trk proto-oncogene. Mol. Cell. Biol. 9, 2433.
  • Matsuda Y. and Fukuda J. (1988) Inhibition by K-252a, a new inhibitor of protein kinase, of nerve growth factor-induced neurite outgrowth of chick embryo dorsal root ganglion cells. Neurosci. Lett. 87, 1117.
  • Matsuda Y., Nakanishi S., Nagasawa K., Iwahashi K., and Kase H. (1988) The effect of K-252a, a potent microbial inhibitor of protein kinase, on activated cyclic nucleotide phosphodiesterase. Biochem. J. 256, 7580.
  • McDonald N. Q., Lapatto R., Murray-Rust J., Gunning J., Wlodawer A., and Blundell T. L. (1991) New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature 354, 411414.
  • Nabeshima T., Ogawa S., Ishimary H., Kameyama T., Fukuda T., Takeuchi R., and Hayashi K. (1991a) Memory impairment and morphological changes in rats induced by active fragment of anti-nerve growth factor antibody. Biochem. Biophys. Res. Commun. 175, 215219.
  • Nabeshima T., Ogawa S., Nishimura H., Fuji K., Kameyama T., and Sasaki Y. (1991b) Staurosporine, a protein kinase inhibitor, attenuates basal forebrain lesion-induced amnesia and cholinergic neuronal deficit. Neurosci. Lett. 122, 1316.
  • Nabeshima T., Ogawa S. I., Nishimura H., Fuji K., Kameyama T., and Sasaki Y. (1991c) Staurosporine facilitates recovery from the basal forebrain lesion-induced impairment of learning and deficit of cholinergic neurons in rats. J. Pharmacol. Exp. Ther. 257, 562566.
  • Nagashima K., Nakanishi S., and Matsuda Y. (1991) Inhibition of nerve growth factor-induced neurite outgrowth of PC12 cells by a protein kinase inhibitor which does not permeate the cell membrane. FEBS Lett. 293, 119123.
  • Nakanishi S., Matsuda Y., Iwahashi K., and Kase H. (1986) K-252b, c, and d, potent inhibitors of protein kinase C from microbial origin. J. Antibiot. 39, 10661071.
  • Nakanishi S., Yamada K., Kase H., Nakamura S., and Nonomura Y. (1988) K-252a, a novel microbial product, inhibits smooth muscle myosin light chain kinase. J. Biol. Chem. 263, 62156219.
  • Nakanishi S., Yamada K., Iwahashi K., Kuroda K., and Kase H. (1990) KT5926, a potent and selective inhibitor of myosin light chain kinase. Mol. Pharmacol. 37, 482488.
  • Nakano H., Kobayashi E., Takahashi I., Tamaoki T., Kuzuu Y., and Iba H. (1987) Staurosporine inhibits tyrosine-specific protein kinase activity of Rous sarcoma virus transforming protein p60. J. Antibiot. 5, 706708.
  • Olson L., Nordberg A., von Holst H., Backman L., Ebendahl T., Alafuzoff I., Amberla K., Hartvig P., Herlitz A., Lilja A., Lundquist H., Langstron B., Meyerson B., Persson A., Viitanen M., Winblad B., and Seiger A. (1992) Nerve growth factor affects 11C-nicotine binding, blood flow, EEG, and verbal episodic memory in an Alzheimer patient. J. Neural Transm. (Park. Dis. Dement. Sect.) 4, 7995.
  • Phillips H. S., Hains J. M., Laramee G. R., Rosenthal A., and Winslow J. W. (1990) Widespread expression of BDNF but not NT3 by target areas of basal forebrain cholinergic neurons. Science 250, 290292.
  • Qiu M. S. and Green S. H. (1991) NGF and EGF rapidly activate p21ras in PC12 cells by distinct, convergent pathways involving tyrosine phosphorylation. Neuron 7, 937946.
  • Radeke M. J., Misko T. P., Hsu C., Herzenberg L. A., and Shooter E. M. (1987) Gene transfer and molecular cloning of the rat nerve growth factor receptor: a new class of receptors. Nature 325, 593597.
  • Rodriguez-Tebar A., Dechant G., and Barde Y. A. (1990) Binding of brain-derived neurotrophic factor to the nerve growth factor receptor. Neuron 4, 487492.
  • Rodriguez-Tebar A., Dechant G., Götz R., and Barde Y. A. (1992) Binding of neurotrophin-3 to its neuronal receptors and interactions with nerve growth factor and brain-derived neurotrophic factor. EMBO J. 11, 917922.
  • Rosenthal A., Goeddel D. V., Nguyen T., Lewis M., Shih A., Laramee G. R., Nikolics K., and Winslow J. W. (1990) Primary structure and biological activity of a novel human neurotrophic factor. Neuron 4, 767773.
  • Sano M., Nishiyama K., and Kitajima S. (1990) A nerve growth factor-dependent protein kinase that phosphorylates microtubule-associated proteins in vitro: possible involvement of its activity in the outgrowth of neurites from PC12 cells. J. Neurochem. 55, 427435.
  • Sarstedt B. and Winterfeldt E. (1983) Reactions with indole derivatives, XLVIII. Heterocylcles 20, 469476.
  • Sezaki M., Sasaki T., Nakazawa T., Takeda U., Iwata M., Watanabe T., Koyama M., Kai F., Shomura T., and Kojima M. (1985) A new antibiotic SF-2370 produced by Actinomadura. J. Antibiot. 38, 14371439.
  • Shea T. B. and Beermann M. L. (1991) Staurosporine-induced morphological differentiation of human neuroblastoma cells. Cell Biol. Int. Rep. 15, 161168.
  • Smith C. J., Court J. A., Keith A. B., and Perry E. K. (1989) Increases in muscarinic-stimulated hydrolysis of inositol phospholipids in rat hippocampus following cholinergic deafferentation are not paralleled by alterations in cholinergic receptor density. Brain Res. 485, 317324.
  • Soppet D., Escandon E., Maragos J., Kaplan D. R., Hunter T., Nikolics K., and Parada L. F. (1991) The neurotrophic factors BDNF and NT-3 are ligands for the trkB tyrosine kinase receptor. Cell 65, 895903.
  • Springer J. E. (1988) Nerve growth factor receptors in the central nervous system. Exp. Neurol. 102, 354365.
  • Squinto S. P., Stitt T. N., Aldrich T. H., Davis S. M., Bianco S. M., Rdziejewski C., Glass D. J., Masiakowski P., Furth M. E., Valenzuela D. M., DiStefano P. S., and Yancopoulos G. D. (1991) trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not NGF. Cell 65, 885893.
  • Thanos S., Bahr M., Barde Y. A., and Vanselow J. (1989) Survival and axonal elongation of adult rat retinal ganglion cells: in vitro effects of lesioned sciatic nerve and brain-derived neurotrophic factor. Eur. J. Neurosci. 1, 1926.
  • Thoenen H. (1991) The changing scene of neurotrophic factors. Trends Neurosci. 14, 165170.
  • Thoenen H., Bandtlow C., and Heumann R. (1987) The physiological function of nerve growth factor in the central nervous system: comparison with the periphery. Rev. Physiol. Biochem. Pharmacol. 109, 145178.
  • Tischler A. S., Ruzicka L. A., and Perlman R. L. (1990) Mimicry and inhibition of nerve growth factor effects: interactions of staurosporine, forskolin, and K-252a in PC12 cells and normal rat chromaffin cells in vitro. J. Neurochem. 55, 11591165.
  • Tischler A. S., Ruzicka L. A., and Dobner P. R. (1991) A protein kinase inhibitor, staurosporine, mimics nerve growth factor induction of neurotensin/neuromedin N gene expression. J. Biol. Chem. 266, 11411146.
  • Tsao H. and Greene L. A. (1991) The roles of macromolecular synthesis and phosphorylation in the regulation of a protein kinase activity transiently stimulated by nerve growth factor. J. Biol. Chem. 266, 1298112988.
  • Tuszynski, M. H. U H. S., Yoshida, K., and Gage F. H. (1991) Recombinant human nerve growth factor infusions prevent cholinergic neuronal degeneration in the adult primate brain. Ann. Neurol. 30, 625636.
  • Ullrich A., Gray A., Tam A. W., Yang-Feng T., Tsubokawa M., Collins C., Henzel W., LeBon T., Kathuria S., Chen E., Jacobs S., Francke U., Ramachandran J., and Fujita-Yamaguchi Y. (1986) Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define function specificity. EMBO J. 5, 25032512.
  • Vetter M. L., Martin-Zanca D., Parada L. F., Bishop J. M., and Kaplan D. R. (1991) Nerve growth factor rapidly stimulates tyrosine phosphorylation of phospholipase C-gamma1 by a kinase activity associated with the product of trk protooncogene. Proc. Natl. Acad. Sci. USA 88, 56505654.
  • Wetmore C., Ernfors P., Persson H., and Olson L. (1990) Localization of brain-derived neurotrophic factor mRNAs to neurons in the brain by in situ hybridization. Exp. Neurol. 109, 141152.
  • Whittemore S. R. and Seiger A. (1987) The expression, localization, and functional significance of beta-nerve growth factor in the central nervous system. Brain Res. Rev. 12, 439464.
  • Yankner B. A. and Shooter E. M. (1982) The biology and mechanism of action of nerve growth factor. Annu. Rev. Biochem. 51, 845868.