Sex Differences in the Effects of Acute Swim Stress on Binding to GABAA Receptors in Mouse Brain
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 60, Issue 6, pages 2212–2216, June 1993
How to Cite
Akinci, M. K. and Johnston, G. A. R. (1993), Sex Differences in the Effects of Acute Swim Stress on Binding to GABAA Receptors in Mouse Brain. Journal of Neurochemistry, 60: 2212–2216. doi: 10.1111/j.1471-4159.1993.tb03507.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received September 3, 1992; revised manuscript received November 13, 1992; accepted November 13, 1992.
- Swim stress;
- Sex differences;
Abstract: Acute swim stress (3-min swim at 32°C) in female, but not in male, mice results in substantial changes in the characteristics of GABA binding to membranes prepared from the forebrain. These changes were larger when measured in a relatively crude membrane preparation than in a well-washed membrane preparation commonly used in GABA binding assays, consistent with the loss of endogenous modulators of GABA binding in the latter preparation. These changes may be related to stress-induced alterations in part in the modulation of the characteristics of GABA binding by endogenous steroids, as the acute swim stress produced a larger increase in plasma corticosterone levels in female than in male mice.