Evidence for Cyclic AMP-Mediated Increase of Aromatic L-Amino Acid Decarboxylase Activity in the Striatum and Midbrain
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 60, Issue 6, pages 2331–2333, June 1993
How to Cite
Young, E. A., Neff, N. H. and Hadjiconstantinou, M. (1993), Evidence for Cyclic AMP-Mediated Increase of Aromatic L-Amino Acid Decarboxylase Activity in the Striatum and Midbrain. Journal of Neurochemistry, 60: 2331–2333. doi: 10.1111/j.1471-4159.1993.tb03525.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received February 12, 1993; accepted March 9, 1993.
- Aromatic L-amino acid decarboxylase;
- Cyclic AMP;
- Protein kinase A;
Abstract: Aromatic L-amino acid decarboxylase (AAAD) activity of mouse striatum and midbrain increased after an intracerebro-ventricular injection of either forskolin or 8-bromo-cyclic AMP. The increase was transient, peaking between 15 and 30 min and returning to baseline by ˜90 min. The increase of AAAD activity after forskolin was not affected by pretreatment with cycloheximide. Kinetic studies indicated an apparent increase of Vmax with little change of the Km for L-DOPA or pyridoxal 5′-phosphate. We conclude that AAAD activity of striatum and midbrain can be modulated by a cyclic AMP-dependent process.