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Keywords:

  • evolution;
  • G protein-coupled receptor;
  • neuropeptide;
  • physiological function;
  • receptor regulation;
  • somatostatin

Abstract

This review summarizes the latest advances that have been made to elucidate the somatostatinergic system in respect to somatostatin receptor evolution, the development of receptor agonists/antagonists, receptor regulation, signal transduction, effects on cell proliferation, receptor–receptor or receptor–protein interactions and receptor function.