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Amniotic fluid brain-specific proteins are biomarkers for spinal cord injury in experimental myelomeningocele

  1. A. Petzold1,
  2. D. Stiefel2,3,
  3. A. J. Copp3

Article first published online: 17 AUG 2005

DOI: 10.1111/j.1471-4159.2005.03432.x

Issue

Journal of Neurochemistry

Journal of Neurochemistry

Volume 95, Issue 2, pages 594–598, October 2005

Additional Information

How to Cite

Petzold, A., Stiefel, D. and Copp, A. J. (2005), Amniotic fluid brain-specific proteins are biomarkers for spinal cord injury in experimental myelomeningocele. Journal of Neurochemistry, 95: 594–598. doi: 10.1111/j.1471-4159.2005.03432.x

Author Information

  1. 1

    Department of Neuroimmunology, Institute of Neurology, Queen Square, London, UK

  2. 2

    Department of Surgery, University Children's Hospital Zurich, Zurich, Switzerland

  3. 3

    Neural Development Unit, Institute of Child Health, University College London, London, UK

*Address correspondence and reprint requests to A. Petzold, Department of Neuroimmunology, Institute of Neurology, Queen Square, London WC1N 3BG, UK. E-mail: a.petzold@ion.ucl.ac.uk

Publication History

  1. Issue published online: 12 SEP 2005
  2. Article first published online: 17 AUG 2005
  3. Received February 8, 2005; revised manuscript received March 15, 2005; accepted March 23, 2005.

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References

  • Adzick N. S., Sutton L. N., Crombleholme T. M. and Flake A. W. (1998) Successful fetal surgery for spina bifida. Lancet 352, 1675–1676.
  • Albrechtsen M., Bock E. and Norgaardpedersen B. (1984) Glial fibrillary acidic protein in amniotic fluids from pregnancies with fetal neural-tube defects. Prenat. Diagn. 4, 405–410.
    Direct Link:
  • Albrechtsen M., Massaro A. and Bock E. (1985) Enzyme-linked immunosorbent assay for the human glial fibrillary acidic protein using a mouse monoclonal antibody. J. Neurochem. 44, 560–506.
    Direct Link:
  • Bell J. E., Barron L. and Raab G. (1994) Antenatal detection of neural tube defects. comparison of biochemical and immunofluorescence methods. Prenat. Diagn. 14, 615–622.
    Direct Link:
  • Bouchard S., Davey M. G., Rintoul N. E., Walsh D. S., Rorke L. B. and Adzick N. S. (2003) Correction of hindbrain herniation and anatomy of the vermis after in utero repair of myelomeningocele in sheep. J. Pediatr Surg. 38, 451–408.
  • Copp A. J., Greene N. D. and Murdoch J. N. (2003) The genetic basis of mammalian neurulation. Nat. Rev. Genet. 4, 784–793.
  • Donato R. (2001) S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int. J. Biochem. Cell Biol. 33, 637–668.
  • Florio P., Michetti F., Bruschettini M., Bruschettini P., Severi F. M., Petraglia F. and Gazzolo D. (2004) Amniotic fluid S100B protein in mid-gestation and intrauterine fetal death. Lancet 364, 270–202.
  • Green A. J. E., Keir G. and Thompson E. J. (1997) A specific and sensitive ELISA for measuring S-100b in cerebrospinal fluid. J. Immunol. Methods 205, 35–41.
  • Hidaka H., Endo T., Kawamoto S., Yamada E., Umekawa H., Tanabe K. and Hara K. (1983) Purification and characterization of adipose tissue S-100b protein. J. Biol. Chem. 258, 2705–2709.
  • Luthy D. A., Wardinsky T., Shurtleff D. B., Hollenbach K. A., Hickok D. E., Nyberg D. A. and Benedetti T. J. (1991) Cesarean section before the onset of labor and subsequent motor function in infants with meningomyelocele diagnosed antenatally. N. Engl. J. Med. 324, 662–606.
  • Lycke J. N., Karlsson J. E., Andersen O. and Rosengren L. E. (1998) Neurofilament protein in cerebrospinal fluid: a potential marker of activity in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry 64, 402–404.
  • Meuli M., Meuli-Simmen C., Yingling C. D., Hutchins G. M., Seller M. J., Harrison M. R. and Adzick N. S. (1995) Creation of myelomeningocele in utero: a model of functional damage from spinal cord exposure in fetal sheep. J. Pediatr. Surg. 30, 1028–1032.
  • Meuli M., Meuli-Simmen C., Hutchins G. M., Hoffman K. M., Harrison M. R. and Adzick N. S. (1997) The spinal cord lesion in human fetuses with myelomeningocele: Implications for fetal surgery. J. Pediatr. Surg. 32, 448–452.
  • Michetti F. and Gazzolo D. (2003) S100B testing in pregnancy. Clin. Chim. Acta 335, 1–7.
  • Michetti F., Lauriola L., Rende M., Stolfi V. M., Battaglia F. and Cocchia D. (1985) S-100 protein in the testis. An immunochemical and immunohistochemical study. Cell Tissue Res. 240, 137–142.
  • Nicholas A. P., Sambandam T., Echols J. D. and Tourtellotte W. W. (2004) Increased citrullinated glial fibrillary acidic protein in secondary progressive multiple sclerosis. J. Comp. Neurol. 473, 128–136.
    Direct Link:
  • Petzold A., Baker D., Pryce G., Keir G., Thompson E. J. and Giovannoni G. (2003a) Quantification of neurodegeneration by measurement of brain-specific proteins. J. Neuroimmunol. 138, 45–48.
  • Petzold A., Keir G., Green A. J. E., Giovannoni G. and Thompson E. J. (2003b) A specific ELISA for measuring neurofilament heavy chain phosphoforms. J. Immunol. Methods 278, 179–190.
  • Petzold A., Keir G., Lim D., Smith M. and Thompson E. J. (2003c) CSF and serum S100B: release and wash-out pattern. Brain Res. Bull. 61, 281–285.
  • Petzold A., Keir G., Green A. J., Giovannoni G. and Thompson E. J. (2004a) An ELISA for glial fibrillary acidic protein. J. Immunol. Methods 287, 169–177.
  • Petzold A., Rejdak K. and Plant G. T. (2004b) Axonal degeneration and inflammation in acute optic neuritis. J. Neurol. Neurosurg. Psychiatry 75, 1178–1780.
  • Petzold A., Eikelenboom M. J., Keir G., Grant D., Lazeron R. H., Polman C. H., Uitdehaag B. M., Thompson E. J. and Giovannoni G. (2005) Axonal damage accumulates in the progressive phase of multiple sclerosis: a 3-year follow-up study. J. Neurol. Neurosurg. Psychiatry 76, 206–211.
  • Pryce G., Ahmed Z., Hankey D. J., Jackson S. J., Croxford J. L., Pocock J. M., Ledent C., Petzold A., Thompson A. J., Giovannoni G., Cuzner M. L. and Baker D. (2003) Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain 127, 2191–2202.
  • Reisert I., Wildemann G., Grab D. and Pilgrim C. (1984) The glial reaction in the course of axon regeneration: a stereological study of the rat hypoglossal nucleus. J. Comp. Neurol. 10, 121–128.
    Direct Link:
  • Semra Y. K., Seidi O. A. and Sharief M. K. (2002) Heightened intrathecal release of axonal cytoskeletal proteins in multiple sclerosis is associated with progressive disease and clinical disability. J. Neuroimmunol. 122, 132–109.
  • Stiefel D., Shibata T., Meuli M., Duffy P. G. and Copp A. J. (2003) Tethering of the spinal cord in mouse fetuses and neonates with spina bifida. J. Neurosurg. Spine 99, 206–213.
  • Takahashi K., Isobe T., Ohtsuki Y., Akagi T., Sonobe H. and Okuyama T. (1984) Immunohistochemical study on the distribution of alpha and beta subunits of S-100 protein in human neoplasm and normal tissues. Virchows Arch. B Cell Pathol. Incl. Mol. Pathol 45, 385–396.
  • Van Regemorter N., Gheuens J., Noppe M., Vamos E., Seller M. J. and Lowenthal A. (1987) Value of glial fibrillary acidic protein determination in amniotic fluid for prenatal diagnosis of neural tube defects. Clin. Chim. Acta 165, 83–88.
  • Yingling C. D., Meuli-Simmen C., Meuli M., Timmel G. B., Adzick N. S. and Harrison M. (1999a) Assessment of sensory function in neonatal sheep with somatosensory evoked potentials: methodology and normative data. Pediatr. Surg. Int. 15, 530–504.
  • Yingling C. D., Meuli-Simmen C., Meuli M., Timmel G. B., Harrison M. and Adzick N. S. (1999b) Experimental fetal neurosurgery: effects of in-utero manipulations on somatosensory evoked potentials. Pediatr. Surg. Int. 15, 535–509.
  • Yoshizawa J., Sbragia L., Paek B. W., Sydorak R. M., Yamazaki Y., Harrison M. R. and Farmer D. L. (2004) Fetal surgery for repair of myelomeningocele allows normal development of anal sphincter muscles in sheep. Pediatr Surg. Int. 20, 14–18.
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