Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity
Article first published online: 21 NOV 2005
Journal of Neurochemistry
Volume 96, Issue 1, pages 78–81, January 2006
How to Cite
Maharaj, D. S., Maharaj, H., Daya, S. and Glass, B. D. (2006), Melatonin and 6-hydroxymelatonin protect against iron-induced neurotoxicity. Journal of Neurochemistry, 96: 78–81. doi: 10.1111/j.1471-4159.2005.03532.x
- Issue published online: 21 NOV 2005
- Article first published online: 21 NOV 2005
- Received May 23, 2005; revised manuscript received July 14, 2005; accepted August 25, 2005.
- oxidative stress
Oxidative damage of biological macromolecules is a hallmark of most neurodegenerative disorders such as Alzheimer, Parkinson and diffuse Lewy body diseases. Another important phenomenon involved in these disorders is the alteration of iron homeostasis, with an increase in iron levels. The present study investigated whether 6-hydroxymelatonin (6-OHM) can reduce Fe2+-induced lipid peroxidation and necrotic cell damage in the rat hippocampus in vivo. It was found that 6-OHM administration proved successful in reducing Fe2+-induced neurotoxicity in rat hippocampus. This study provides some evidence of the neuroprotective effects of 6-OHM.