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  • Bartus R. T., Dean R. L., 3rd, Beer B. and Lippa A. S. (1982) The cholinergic hypothesis of geriatric memory dysfunction. Science 217, 408414.
  • Baxter M. G. and Chiba A. A. (1999) Cognitive functions of the basal forebrain. Curr. Opin. Neurobiol. 9, 178183.
  • Bennett D. A., Wilson R. S., Schneider J. A., Evans D. A., Beckett L. A., Aggarwal N. T., Barnes L. L., Fox J. H. and Bach J. (2002) Natural history of mild cognitive impairment in older persons. Neurology 59, 198205.
  • Bierer L. M., Haroutunian V., Gabriel S., Knott P. J., Carlin L. S., Purohit D. P., Perl D. P., Schmeidler J., Kanof P. and Davis K. L. (1995) Neurochemical correlates of dementia severity in Alzheimer's disease: relative importance of the cholinergic deficits. J. Neurochem. 64, 749760.
  • Boissiere F., Faucheux B., Ruberg M., Agid Y. and Hirsch E. C. (1997) Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease. Exp Neurol. 145, 245252.
  • Braak H. and Braak E. (1991) Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol. 82, 239259.
  • Capsoni S., Ugolini G., Comparini A., Ruberti F., Berardi N. and Cattaneo A. (2000) Alzheimer-like neurodegeneration in aged antinerve growth factor transgenic mice. Proc. Natl Acad. Sci. USA 97, 68266831.
  • Che S. and Ginsberg S. D. (2004) Amplification of transcripts using terminal continuation. Lab. Invest. 84, 131137.
  • Chu Y., Cochran E. J., Bennett D. A., Mufson E. J. and Kordower J. H. (2001) Down-regulation of trkA mRNA within nucleus basalis neurons in individuals with mild cognitive impairment and Alzheimer's disease. J. Comp Neurol. 437, 296307.
  • Cooper J. D., Lindholm D. and Sofroniew M. V. (1994) Reduced transport of [125I]nerve growth factor by cholinergic neurons and down-regulated TrkA expression in the medial septum of aged rats. Neuroscience 62, 625629.
  • Cooper J. D., Salehi A., Delcroix J. D., Howe C. L., Belichenko P. V., Chua-Couzens J., Kilbridge J. F., Carlson E. J., Epstein C. J. and Mobley W. C. (2001) Failed retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic neurodegenerative phenotypes following NGF infusion. Proc. Natl Acad. Sci. USA 98, 10 43910 444.
  • Counts S. E., Chen E.-Y., Che S., Ikonomovic M. D., Wuu J., Ginsberg S. D., DeKosky S. T. and Mufson E. J. (2006) Galanin fiber hypertrophy within the cholinergic nucleus basalis during the progression of Alzheimer's disease. Dement. Geriatr. Cogn. Disord. 21, 205221.
  • Counts S. E. and Mufson E. J. (2005) The role of nerve growth factor receptors in cholinergic basal forebrain degeneration in prodromal Alzheimer's disease. J. Neuropath. Exper. Neurol. 64, 263272.
  • Counts S. E., Nadeem M., Wuu J., Ginsberg S. D., Saragovi H. U. and Mufson E. J. (2004) Reduction of cortical TrkA but not p75 (NTR) protein in early-stage Alzheimer's disease. Ann. Neurol. 56, 520531.
  • De Lacalle S., Cooper J. D., Svendsen C. N., Dunnett S. B. and Sofroniew M. V. (1996) Reduced retrograde labelling with fluorescent tracer accompanies neuronal atrophy of basal forebrain cholinergic neurons in aged rats. Neuroscience 75, 1927.
  • DeKosky S. T., Ikonomovic M. D., Styren S. D., Beckett L., Wisniewski S., Bennett D. A., Cochran E. J., Kordower J. H. and Mufson E. J. (2002) Upregulation of choline acetyltransferase activity in hippocampus and frontal cortex of elderly subjects with mild cognitive impairment. Ann. Neurol. 51, 145155.
  • Eberwine J., Kacharmina J. E., Andrews C., Miyashiro K., McIntosh T., Becker K., Barrett T., Hinkle D., Dent G. and Marciano P. (2001) mRNA expression analysis of tissue sections and single cells. J. Neurosci. 21, 83108314.
  • Fahnestock M., Yu G., Michalski B., Mathew S., Colquhoun A., Ross G. M. and Coughlin M. D. (2004) The nerve growth factor precursor proNGF exhibits neurotrophic activity but is less active than mature nerve growth factor. J. Neurochem. 89, 581592.
  • Galvin J. E. and Ginsberg S. D. (2004) Expression profiling and pharmacotherapeutic development in the central nervous system. Alzheimer Dis Assoc Disord 18, 264269.
  • Galvin J. E. and Ginsberg S. D. (2005) Expression profiling in the aging brain: a perspective. Ageing Res. Rev. 4, 529547.
  • Gilmor M. L., Erickson J. D., Varoqui H., Hersh L. B., Bennett D. A., Cochran E. J., Mufson E. J. and Levey A. I. (1999) Preservation of nucleus basalis neurons containing choline acetyltransferase and the vesicular acetylcholine transporter in the elderly with mild cognitive impairment and early Alzheimer's disease. J. Comp Neurol. 411, 693704.
  • Ginsberg S. D. (2005) RNA amplification strategies for small sample populations. Methods 37, 229237.
  • Ginsberg S. D. and Che S. (2002) RNA amplification in brain tissues. Neurochem. Res. 27, 981992.
  • Ginsberg S. D. and Che S. (2004) Combined histochemical staining, RNA amplification, regional, and single cell analysis within the hippocampus. Lab. Invest. 84, 952962.
  • Ginsberg S. D. and Che S. (2005) Expression profile analysis within the human hippocampus: Comparison of CA1 and CA3 pyramidal neurons. J. Comp Neurol. 487, 107118.
  • Ginsberg S. D., Crino P. B., Lee V. M.-Y., Eberwine J. H. and Trojanowski J. Q. (1997) Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques. Ann. Neurol. 41, 200209.
  • Ginsberg S. D., Galvin J. E., Chiu T.-S., Lee V. M.-Y., Masliah E. and Trojanowski J. Q. (1998) RNA sequestration to pathological lesions of neurodegenerative disorders. Acta Neuropathol. 96, 487494.
  • Ginsberg S. D., Hemby S. E., Lee V. M.-Y., Eberwine J. H. and Trojanowski J. Q. (2000) Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons. Ann. Neurol. 48, 7787.
  • Ginsberg S. D., Hemby S. E., Mufson E. J. and Martin L. J. (2006) Cell and tissue microdissection in combination with genomic and proteomic applications, in Neuroanatomical Tract Tracing 3. Molecules-Neurons-Systems (Zaborszky, L., Wouterlood, F. and Lanciego, J. L., eds), pp. 109141 Springer/Kluwer/Plenum, New York.
  • Higgins G. A. and Mufson E. J. (1989) NGF receptor gene expression is decreased in the nucleus basalis in Alzheimer's disease. Exp Neurol. 106, 222236.
  • Holtzman D. M., Li Y., Parada L. F., Kinsman S., Chen C. K., Valletta J. S., Zhou J., Long J. B. and Mobley W. C. (1992) p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGF. Neuron 9, 465478.
  • Howe C. L. and Mobley W. C. (2004) Signaling endosome hypothesis: a cellular mechanism for long distance communication. J. Neurobiol. 58, 207216.
  • Hyman B. T. and Trojanowski J. Q. (1997) Consensus recommendations for the post-mortem diagnosis of Alzheimer disease from the National Institute on Aging and the Reagan Institute Working Group on diagnostic criteria for the neuropathological assessment of Alzheimer disease. J. Neuropathol. Exp. Neurol. 56, 10951097.
  • Johnson D., Lanahan A., Buck C. R., Sehgal A., Morgan C., Mercer E., Bothwell M. and Chao M. (1986) Expression and structure of the human NGF receptor. Cell 47, 545554.
  • Kaplan D. R. and Miller F. D. (2000) Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol. 10, 381391.
  • Li Y., Holtzman D. M., Kromer L. F., Kaplan D. R., Chua-Couzens J., Clary D. O., Knusel B. and Mobley W. C. (1995) Regulation of TrkA and ChAT expression in developing rat basal forebrain: evidence that both exogenous and endogenous NGF regulate differentiation of cholinergic neurons. J. Neurosci. 15, 28882905.
  • Mesulam M. M., Mufson E. J., Levey A. I. and Wainer B. H. (1983) Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey. J. Comp Neurol. 214, 170197.
  • Mirra S. S., Heyman A., McKeel D., Sumi S. M., Crain B. J., Brownlee L. M., Vogel F. S., Hughes J. P., van Belle G. and Berg L. (1991) The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 41, 479486.
  • Mufson E. J., Bothwell M., Hersh L. B. and Kordower J. H. (1989b) Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: colocalization with cholinergic neurons. J. Comp Neurol. 285, 196217.
  • Mufson E. J., Bothwell M. and Kordower J. H. (1989a) Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain. Exp Neurol. 105, 221232.
  • Mufson E. J., Counts S. E., Che S. and Ginsberg S. D. (2004) cDNA array and quantitative PCR analysis of neurotrophin receptor transcripts in cholinergic basal forebrain neurons in people with mild cognitive impairment (MCI) and Alzheimer's disease. Proc. Soc. Neurosci. 30, 335–336.
  • Mufson E. J., Counts S. E. and Ginsberg S. D. (2002) Single cell gene expression profiles of nucleus basalis cholinergic neurons in Alzheimer's disease. Neurochem. Res. 27, 10351048.
  • Mufson E. J., Ginsberg S. D., Ikonomovic M. D. and DeKosky S. T. (2003) Human cholinergic basal forebrain: chemoanatomy and neurologic dysfunction. J. Chem. Neuroanat 26, 233242.
  • Mufson E. J. and Kordower J. H. (1992) Cortical neurons express nerve growth factor receptors in advanced age and Alzheimer disease. Proc. Natl Acad. Sci. USA 89, 569573.
  • Mufson E. J., Lavine N., Jaffar S., Kordower J. H., Quirion R. and Saragovi H. U. (1997) Reduction in p140-trkA receptor protein within the nucleus basalis and cortex in Alzheimer's disease. Exp. Neurol. 146, 91103.
  • Mufson E. J., Li J. M., Sobreviela T. and Kordower J. H. (1996) Decreased trkA gene expression within basal forebrain neurons in Alzheimer's disease. Neuroreport 8, 2529.
  • Mufson E. J., Ma S. Y., Cochran E. J., Bennett D. A., Beckett L. A., Jaffar S., Saragovi H. U. and Kordower J. H. (2000) Loss of nucleus basalis neurons containing trkA immunoreactivity in individuals with mild cognitive impairment and early Alzheimer's disease. J. Comp Neurol. 427, 1930.
  • Naumann T., Casademunt E., Hollerbach E., Hofmann J., Dechant G., Frotscher M. and Barde Y. A. (2002) Complete deletion of the neurotrophin receptor p75NTR leads to long-lasting increases in the number of basal forebrain cholinergic neurons. J. Neurosci. 22, 24092418.
  • Nykjaer A., Lee R., Teng K. K. et al. (2004) Sortilin is essential for proNGF-induced neuronal cell death. Nature 427, 843848.
  • Pedraza C. E., Podlesniy P., Vidal N., Arevalo J. C., Lee R., Hempstead B., Ferrer I., Iglesias M. and Espinet C. (2005) Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR. Am. J. Pathol 166, 533543.
  • Peng S., Wuu J., Mufson E. J. and Fahnestock M. (2004) Increased proNGF levels in subjects with mild cognitive impairment and mild Alzheimer disease. J. Neuropathol Exp Neurol. 63, 641649.
  • Peng S., Wuu J., Mufson E. J. and Fahnestock M. (2005) Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J. Neurochem. 93, 14121421.
  • Petersen R. C. (2004) Mild cognitive impairment as a diagnostic entity. J. Intern. Med. 256, 183194.
  • Ruberti F., Capsoni S., Comparini A., Di Daniel E., Franzot J., Gonfloni S., Rossi G., Berardi N. and Cattaneo A. (2000) Phenotypic knockout of nerve growth factor in adult transgenic mice reveals severe deficits in basal forebrain cholinergic neurons, cell death in the spleen, and skeletal muscle dystrophy. J. Neurosci. 20, 25892601.
  • Salehi A., Verhaagen J., Dijkhuizen P. A. D. and Swaab D. F. (1996) Co-localization of high-affinity neurotrophin receptors in nucleus basalis of Meynert neurons and their differential reduction in Alzheimer's disease. Neuroscience 75, 373387.
  • Saragovi H. U. (2005) Progression of age-associated cognitive impairment correlates with quantitative and qualitative loss of TrkA receptor protein in nucleus basalis and cortex. J. Neurochem. 95, 14721480.
  • SAS Institute. (1999) SAS/STAT User's Guide, Version 8. SAS Publishing, Cary, NC, USA.
  • Schatteman G. C., Gibbs L., Lanahan A. A., Claude P. and Bothwell M. (1988) Expression of NGF receptor in the developing and adult primate central nervous system. J. Neurosci. 8, 860873.
  • Shelton D. L., Sutherland J., Gripp J., Camerato T., Armanini M. P., Phillips H. S., Carroll K., Spencer S. D. and Levinson A. D. (1995) Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J. Neurosci. 15, 477491.
  • Sofroniew M. V., Howe C. L. and Mobley W. C. (2001) Nerve growth factor signaling, neuroprotection, and neural repair. Annu. Rev. Neurosci. 24, 12171281.
  • Teng K. K. and Hempstead B. L. (2004) Neurotrophins and their receptors: signaling trios in complex biological systems. Cell Mol Life Sci. 61, 3548.
  • Tuszynski M. H. (2002) Growth-factor gene therapy for neurodegenerative disorders. Lancet Neurol. 1, 5157.
  • Tuszynski M. H., Thal L., Pay M. et al. (2005) A Phase I clinical trial of nerve growth factor gene therapy for Alzheimer's disease. Nat. Med. 11, 551555.
  • Whitehouse P. J., Price D. L., Struble R. G., Clark A. W., Coyle J. T. and Delong M. R. (1982) Alzheimer's disease and senile dementia: loss of neurons in the basal forebrain. Science 215, 12371239.
  • Wilcock G. K., Esiri M. M., Bowen D. M. and Smith C. C. (1982) Alzheimer's disease. Correlation of cortical choline acetyltransferase activity with the severity of dementia and histological abnormalities. J. Neurol. Sci. 57, 407417.
  • Winblad B., Palmer K., Kivipelto M. et al. (2004) Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment. J. Intern. Med. 256, 240246.
  • Yang Y., Mufson E. J. and Herrup K. (2003) Neuronal cell death is preceded by cell cycle events at all stages of Alzheimer's disease. J. Neurosci. 23, 25572563.
  • Yoon S. O., Casaccia-Bonnefil P., Carter B. and Chao M. V. (1998) Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival. J. Neurosci. 18, 32733281.