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References

  • Almeida C. G., Tampellini D., Takahashi R. H., Greengard P., Lin M. T., Snyder E. M. and Gouras G. K. (2005) β-Amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Neurobiol. Dis. 20, 187198.
  • Billings L. M., Oddo S., Green K. N. et al. (2005) Intraneuronal Aβ causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45, 675688.
  • Blanchard B. J., Chen A., Rozeboom L. M. et al. (2004) Efficient reversal of Alzheimer's disease fibril formation and elimination of neurotoxicity by a small molecule. Proc. Natl Acad. Sci. USA 101, 1432614332.
  • Casas C., Sergeant N., Itier J. M. et al. (2004) Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Aβ42 accumulation in a novel Alzheimer transgenic model. Am. J. Pathol. 165, 12891300.
  • Cataldo A. M., Petanceska S., Terio N. B. et al. (2004) Aβ localization in abnormal endosomes: association with earliest Aβ elevations in AD and Down's syndrome. Neurobiol. Aging 25, 12631272.
  • Chromy B. A., Nowak R. J., Lambert M. P. et al. (2003) Self-assembly of Aβ(1–42) into globular neurotoxins. Biochemistry 42, 12 74912 760.
  • Dahlgren K. N., Manelli A. M., Stine W. B. Jr et al. (2002) Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability. J. Biol. Chem. 277, 32 04632 053.
  • Doerfler P., Shearman M. S. and Perlmutter R. M. (2001) Presenilin-dependent γ-secretase activity modulates thymocyte development. Proc. Natl Acad. Sci. USA 98, 93129317.
  • Gouras G. K., Almeida C. G. and Takahashi R. H. (2005) Intraneuronal Aβ accumulation and origin of plaques in Alzheimer's disease. Neurobiol. Aging 26, 12351244.
  • Greene L. A. (1978) Nerve growth factor prevents the death and stimulates the neuronal differentiation of clonal PC12 pheochromocytoma cells in serum-free medium. J. Cell Biol. 78, 747755.
  • Hua D. H., Chen Y., Sin H.-S. et al. (1997a) A one-pot condensation of pyrones and enals. Synthesis of 1H,7H−5a,6,8,9-tetrahydrol.-1-oxopyrano[4,3-b][1]benzopyrans. J. Org. Chem. 62, 68886896.
  • Hua D. H., Chen Y., Robinson P. D. et al. (1997b) (5aS,7S)-7-Isopropenyl-3-methyl-5a,6,8,9-tetrahydro-1H,7H–pyrano[4,3–b][1]–benzo-pyran-1-one. Acta Cryst. C53, 19951997.
  • Hua D. H., Huang X., Tamura M. et al. (2003) Synthesis and bioactivities of tricyclic pyrones. Tetrahedron 59, 47954803.
  • Hutter-Paier B., Huttunen H. J., Puglielli L. et al. (2004) The ACAT inhibitor CP-113,818 markedly reduces amyloid pathology in a mouse model of Alzheimer's disease. Neuron 44, 227238.
  • Inestrosa N. C., Alvarez A., Perez C. A. et al. (1996) Acetylcholinesterase accelerates assembly of amyloid-β-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme. Neuron 16, 881891.
  • Ishii K., Klunk W. E., Arawaka S. et al. (2002) Chrysamine G and its derivative reduce amyloid β-induced neurotoxicity in mice. Neurosci. Lett. 333, 58.
  • Jin L.-W., Hua D. H., Shie F. S. et al. (2002) Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death. J. Mol. Neurosci. 19, 5761.
  • Jin L.-W., Maezawa I., Vincent I. et al. (2004) Intracellular accumulation of amyloidogenic fragments of amyloid-β precursor protein in neurons with Niemann–Pick-type C defects is associated with endosomal abnormalities. Am. J. Pathol. 164, 975985.
  • Karlsson R. (2004) SPR for molecular interaction analysis: a review of emerging application areas. J. Mol. Recognit. 17, 151161.
  • Kayed R., Sokolov Y., Edmonds B. et al. (2004) Permeabilization of lipid bilayers is a common conformation-dependent activity of soluble amyloid oligomers in protein misfolding diseases. J. Biol. Chem. 279, 46 36346 366.
  • Kienlen-Campard P., Miolet S., Tasiaux B. et al. (2002) Intracellular amyloid-β1–42, but not extracellular soluble amyloid-β peptides, induces neuronal apoptosis. J. Biol. Chem. 277, 15 66615 670.
  • Lim G. P., Chu T., Yang F. et al. (2001) The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse. J. Neurosci. 21, 83708377.
  • Lipinski C. A., Lombardo F., Dominy B. W. and Feeney P. J. (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug Deliv. Rev. 23, 325.
  • Lorenzo A. and Yankner B. A. (1994) β-Amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc. Natl Acad. Sci. USA 91, 12 24312 247.
  • Lu D. C., Rabizadeh S., Chandra S. et al. (2000) A second cytotoxic proteolytic peptide derived from amyloid β-protein precursor. Nat. Med. 6, 397404.
  • Maezawa I., Jin L.-W., Woltjer R. L. et al. (2004) Apolipoprotein E isoforms and apolipoprotein AI protect from amyloid precursor protein carboxy terminal fragment-mediated cytotoxicity through different mechanisms. J. Neurochem. 91, 13121321.
  • Myszka D. G. (2004) Analysis of small-molecule interactions using Biacore S51 technology. Anal. Biochem. 329, 316323.
  • Omura S., Tomoda H., Kim Y. K. et al. (1993) Pyripyropenes, highly potent inhibitors of acyl-CoA: cholesterol acyltransferase produced by Aspergillus fumigatus. J. Antibiot. 46, 11681169.
  • Omura S., Kuno F., Otoguro K. et al. (1995) Arisugacin, a novel and selective inhibitor of acetylcholinesterase from Penicillium sp. FO-4259. J. Antibiot. 48, 745746.
  • Pike C. J., Burdick D., Walencewicz A. J. et al. (1993) Neurodegeneration induced by β-amyloid peptides in vitro: the role of peptide assembly state. J. Neurosci. 13, 16761687.
  • Podlisny M. B., Walsh D. M., Amarante P. et al. (1998) Oligomerization of endogenous and synthetic amyloid β-protein at nanomolar levels in cell culture and stabilization of monomer by Congo red. Biochemistry 37, 36023611.
  • Shie F. S., LeBoeuf R. C. and Jin L. W. (2003) Early intraneuronal Aβ deposition in the hippocampus of APP transgenic mice. Neuroreport 14, 123129.
  • Sopher B. L., Fukuchi K., Smith A. C. et al. (1994) Cytotoxicity mediated by conditional expression of a carboxyl-terminal derivative of the β-amyloid precursor protein. Brain Res. Mol. Brain Res. 26, 207217.
  • Sopher B. L., Fukuchi K., Kavanagh T. J. et al. (1996) Neurodegenerative mechanisms in Alzheimer's disease. A role for oxidative damage in amyloid β protein precursor-mediated cell death. Mol. Chem. Neuropathol. 29, 153168.
  • De Souza R. F., Sussuchi E. M. and De Giovani W. F. (2003) Synthesis, electrochemical, spectral, and antioxidant properties of complexes of flavanoids with metal ions. Syn. React. Inorg. Metalorg. Chem. 33, 11251144.
  • Takahashi R. H., Almeida C. G., Kearney P. F. et al. (2004) Oligomerization of Alzheimer's β-amyloid within processes and synapses of cultured neurons and brain. J. Neurosci. 24, 35923599.
  • Tan S., Sagara Y., Liu Y. et al. (1998) The regulation of reactive oxygen species production during programmed cell death. J. Cell Biol. 141, 14231432.
  • Thinakaran G., Teplow D. B., Siman R. et al. (1996) Metabolism of the ‘Swedish’ amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the ‘β-secretase’ site occurs in the golgi apparatus. J. Biol. Chem. 271, 93909397.
  • Tjernberg L. O., Naslund J., Lindqvist F. et al. (1996) Arrest of β-amyloid fibril formation by a pentapeptide ligand. J. Biol. Chem. 271, 85458548.
  • Walsh D. M., Tseng B. P., Rydel R. E. et al. (2000) The oligomerization of amyloid β-protein begins intracellularly in cells derived from human brain. Biochemistry 39, 10 83110 839.
  • Walsh D. M., Klyubin I., Fadeeva J. V. et al. (2002) Amyloid-β oligomers: their production, toxicity and therapeutic inhibition. Biochem. Soc. Trans. 30, 552557.
  • Walsh D. M., Townsend M., Podlisny M. B. et al. (2005) Certain inhibitors of synthetic amyloid β-peptide (Aβ) fibrillogenesis block oligomerization of natural Aβ and thereby rescue long-term potentiation. J. Neurosci. 25, 24552462.
  • Wirths O., Multhaup G. and Bayer T. A. (2004) A modified β-amyloid hypothesis: intraneuronal accumulation of the β-amyloid peptide – the first step of a fatal cascade. J. Neurochem. 91, 513520.
  • Woltjer R. L., Nghiem W., Maezawa I. et al. (2005) Role of glutathione in intracellular amyloid-α precursor protein/carboxy-terminal fragment aggregation and associated cytotoxicity. J. Neurochem. 93, 10471056.
  • Yang F., Lim G. P., Begum A. N. et al. (2005) Curcumin inhibits formation of Aβ oligomers and fibrils and binds plaques and reduces amyloid in vivo. J. Biol. Chem. 280, 58925901.
  • Zhang Y., McLaughlin R., Goodyer C. et al. (2002) Selective cytotoxicity of intracellular amyloid β peptide 1–42 through p53 and Bax in cultured primary human neurons. J. Cell Biol. 156, 519529.