Glycine receptors: recent insights into their structural organization and functional diversity
Article first published online: 19 JUN 2006
Journal of Neurochemistry
Volume 97, Issue 6, pages 1600–1610, June 2006
How to Cite
Betz, H. and Laube, B. (2006), Glycine receptors: recent insights into their structural organization and functional diversity. Journal of Neurochemistry, 97: 1600–1610. doi: 10.1111/j.1471-4159.2006.03908.x
- Issue published online: 19 JUN 2006
- Article first published online: 19 JUN 2006
- Received March 8, 2006; revised manuscript received March 13, 2006; accepted March 13, 2006.
- homology modelling;
- ligand-gated ion channel;
- pain sensitization;
- synaptic inhibition
Strychnine-sensitive glycine receptors (GlyRs) are known to mediate synaptic inhibition in spinal cord, brainstem and other regions of the CNS. During the past 5 years, considerable progress has been made in delineating structural determinants of ligand binding and channel activation in recombinant GlyRs. Furthermore, immunohistochemical and gene inactivation studies have disclosed distinct distributions and functions of differentially expressed GlyR subtypes in retina, hippocampus and the dorsal horn of the spinal cord. Accordingly, GlyRs regulate not only the excitability of motor and sensory neurones, but are also essential for the processing of photoreceptor signals, neuronal development and inflammatory pain sensitization. Hence, these receptors constitute promising targets for the development of clinically useful compounds.