SEARCH

SEARCH BY CITATION

References

  • Aoyama K., Suh S. W., Hamby A. M., Liu J., Chan W. Y., Chen Y. and Swanson R. A. (2006) Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat. Neurosci. 9, 119126.
  • Arriza J. L., Eliasov S., Kavanaugh M. P. and Amara S. G. (1997) Excitatory amino acid transporter 5, a retinal glutamate transporter coupled to a chloride conductance. Proc. Natl Acad. Sci. USA 94, 41554160.
  • Ben Ari Y. (2002) Excitatory action of GABA during development: the nature of the nurture. Nat. Rev. Neurosci. 3, 728739.
  • Benjamin A. M. and Quastel J. H. (1975) Metabolism of amino acids and ammonia in rat brain cortex slices in vitro: a possible role of ammonia in brain function. J. Neurochem. 43, 13691374.
  • Bergles D. E., Diamond J. S. and Jahr C. E. (1999) Clearance of glutamate inside the synapse and beyond. Curr. Opin. Neurobiol. 9, 293298.
  • Bortolotto Z. A., Fitzjohn S. M. and Collingridge G. L. (1999) Roles of metabotropic glutamate receptors in LTP and LTD in the hippocampus. Curr. Opin. Neurobiol. 9, 299304.
  • Butchbach M. E., Lai L. and Lin C. L. (2002) Molecular cloning, gene structure, expression profile and functional characterization of the mouse glutamate transporter (EAAT3) interacting protein GTRAP3-18. Gene 292, 8190.
  • Canolle B., Masmejean F., Melon C., Nieoullon A., Pisano P. and Lortet S. (2004) Glial soluble factors regulate the activity and expression of the neuronal glutamate transporter EAAC1: implication of cholesterol. J. Neurochem. 88, 15211532.
  • Casado M., Bendahan A., Zafra F., Danbolt N. C., Aragon C., Gimenez C. and Kanner B. I. (1993) Phosphorylation and modulation of brain glutamate transporters by protein kinase C. J. Biol. Chem. 268, 27 31327 317.
  • Chaudhry F. A., Lehre K. P., Campagne M. V., Ottersen O. P., Danbolt N. C. and Storm-Mathisen J. (1995) Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry. Neuron 15, 711720.
  • Chen Y. and Swanson R. A. (2003) The glutamate transporters EAAT2 and EAAT3 mediated cysteine uptake in cortical neuron culture. J. Neurochem. 84, 13321339.
  • Cheng C., Glover G., Banker G. and Amara S. G. (2002) A novel sorting motif in the glutamate transporter excitatory amino acid transporter 3 directs its targeting in Madin-Darby canine kidney cells and hippocampal neurons. J. Neurosci. 22, 10 64310 652.
  • Coco S., Verderio C., Trotti D., Rothstein J. D., Volterra A. and Matteoli M. (1997) Non-synaptic localization of the glutamate transporter EAAC1 in cultured hippocampal neurons. Eur. J. Neurosci. 9, 19021910.
  • Conti F., DeBiasi S., Minelli A., Rothstein J. D. and Melone M. (1998) EAAC1, a high affinity glutamate transporter, is localized to astrocytes and GABAergic neurons besides pyramidal cells in the rat cerebral cortex. Cereb. Cortex 8, 108116.
  • Crino P. B., Jin H., Shumate M. D., Robinson M. B., Coulter D. A. and Brooks-Kayal A. R. (2002) Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy. Epilepsia 43, 211218.
  • Danbolt N. C. (2001) Glutamate uptake. Prog. Neurobiol. 65, 1105.
  • Danbolt N. C., Chaudhry F. A., Dehnes Y., Lehre K. P., Levy L. M., Ullensvang K. and Storm-Mathisen J. (1998) Properties and localization of glutamate transporters. Prog. Brain Res. 116, 2343.
  • Davis K. E., Straff D. J., Weinstein E. A., Bannerman P. G., Correale D. M., Rothstein J. D. and Robinson M. B. (1998) Multiple signalling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of glutamate transporter in C6 glioma. J. Neurosci. 18, 24752485.
  • Dehnes Y., Chaudhry F. A., Ullensvang K., Lehre K. P., Storm-Mathisen J. and Danbolt N. C. (1998) The glutamate transporter EAAT4 in rat cerebellar Purkinje cells: a glutamate-gated chloride channel concentrated near the synapse in parts of the dendritic membrane facing astroglia. J. Neurosci. 18, 36063619.
  • Doble A. (1999) The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol. Rev. 81, 163221.
  • Dowd L. A. and Robinson M. B. (1996) Rapid stimulation of EAAC1-mediated Na+ dependent 1-glutamate transport activity in C6 glioma cells by phorbol ester. J. Neurochem. 67, 508516.
  • Dringen R. (2000) Metabolism and functions of glutathione in brain. Prog. Neurobiol. 62, 649671.
  • Eskandari S., Kreman M., Kavanaugh M. P., Wright E. M. and Zampighi G. A. (2000) Pentameric assembly of a neuronal glutamate transporter. Proc. Natl Acad. Sci. USA 97, 86418646.
  • Esslinger C. S., Agarwal S., Gerdes J. et al. (2005) The substituted aspartate analogue 1-beta-threo-benzyl-aspartate preferentially inhibits the neuronal excitatory amino acid transporter EAAT3. Neuropharmacology 49, 850861.
  • Fairman W. A., Vanderberg R. J., Arriza J. L., Kavanaugh M. P. and Amara S. G. (1995) An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature 375, 599603.
  • Fonnum F. (1984) Glutamate: a neurotransmitter in mammalian brain. J. Neurochem. 42, 111.
  • Fournier K. M., Gonzales M. I. and Robinson M. B. (2004) Rapid trafficking of the neuronal glutamate transporter, EAAC1. J. Biol. Chem. 279, 34 50534 513.
  • Furuta A., Martin L. J., Lin C. L., Dykes-Hoberg M. and Rothstein J. D. (1997) Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4. Neuroscience 81, 19311042.
  • Furuta A., Noda M., Susuki S. O., Goto Y., Kanahori Y., Rothstein J. D. and Iwaki T. (2003) Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy. Am. J. Pathol. 163, 779787.
  • Gebhardt C., Körner R. T. and Heinemann U. (2002) Delayed anoxic depolarizations in hippocampal neurons of mice lacking the excitatory amino acid carrier 1. J. Cereb. Blood Flow Metab. 22, 569575.
  • Gegelashvili G. and Schousboe A. (1998) Cellular distribution and kinetic properties of high affinity glutamate transporters. Brain Res. Bull. 45, 233238.
  • Gegelashvili G., Dehnes Y., Danbolt N. C. and Schousboe A. (2000) The high-affinity glutamate transporters GLT1, GLAST and EAAT4 are regulated via different signalling mechanisms. Neurochem. Int. 37, 163170.
  • Gonzales M. I. and Robinson M. B. (2004) Protein kinase C-dependent remodeling of glutamate transporter function. Mol. Intervent. 4, 4858.
  • Gonzales M. I., Kazanietz M. G. and Robinson M. B. (2002) Regulation of the neuronal glutamate transporter excitatory amino acid carrier-1 (EAAC1) by different protein kinase C subtype. Mol. Pharmacol. 62, 901910.
  • Gonzales M. I., Bannerman P. G. and Robinson M. B. (2003) Phorbol myristate acetate-dependent interaction of protein kinase Calpha and the neuronal glutamate transporter EAAC1. J. Neurosci. 23, 55895593.
  • Gottlieb M., Domercq M. and Matute C. (2000) Altered expression of the glutamate transporter EAAC1 in neurons and immature oligodendrocytes after transient forebrain ischemia. J. Cereb. Blood Flow Metab. 20, 678687.
  • Grunewald M., Menaker D. and Kanner B. I. (2002) Cysteine-scanning mutagenesis reveals a conformationally sensitive reentrant pore-loop in the glutamate transporter GLT-1. J. Biol. Chem. 277, 26 07426 080.
  • Gu Q. B., Zhao J. X., Fei J. and Schwarz W. (2004) Modulation of Na(+), K(+) pumping and neurotransmitter uptake by beta-amyloid. Neuroscience 126, 6167.
  • Guillet B., Lortet S., Masmejean F., Samuel D., Nieoullon A. and Pisano P. (2002) Developmental expression and activity of high affinity glutamate transporters in rat cortical primary cultures. Neurochem. Int. 40, 661671.
  • Guillet B. A., Velly L. J., Canolle B., Masmejean F. M., Nieoullon A. L. and Pisano P. (2005) Differential regulation by protein kinases of activity and cell surface expression of glutamate transporters in neuron-enriched cultures. Neurochem. Int. 46, 337346.
  • Hardingham G. E., Fukunaga Y. and Bading H. (2002) Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways. Nat. Neurosci. 5, 405414.
  • Harmar A. J., Arimura A., Gozes I. et al. (1998) Nomenclature of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase-activating polypeptide. Pharmacol. Rev. 50, 265270.
  • Haugeto O., Ullensvang K., Levy L. M., Chaudhry F. A., Honore T., Nielsen M., Lehre K. P. and Danbolt N. C. (1996) Brain glutamate transporter proteins form homomultimers. J. Biol. Chem. 271, 27 71527 722.
  • He Y., Janssen W. G. M., Rothstein J. D. and Morrison J. H. (2000) Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus. J. Comp. Neurol. 418, 255269.
  • Hering H., Lin C. C. and Sheng M. (2003) Lipid rafts in the maintenance of synapses, dendritic spines and surface AMPA receptor stability. J. Neurosci. 23, 32623271.
  • Hertz L. and Zieke H. R. (2004) Astrocytic control of glutamatergic activity: astrocytes as stars of the show. Trends Neurosci. 27, 735743.
  • Himi T., Ikeda M., Yasuhara T., Nishida M. and Morita I. (2003) Role of neuronal glutamate transporter in the cysteine uptake and intracellular glutathione levels in cultured cortical neurons. J. Neural Trans. 110, 13371348.
  • Huang K. and El-Husseini A. (2005) Modulation of neuronal protein trafficking and function by palmitoylation. Curr. Opin. Neurobiol. 15, 527535.
  • Jain A., Martensson J., Stole E., Auld P. A. and Meister A. (1991) Glutathione deficiency leads to mitochondrial damage in the brain. Proc. Natl Acad. Sci. USA 88, 19131917.
  • Kanai Y. and Hediger M. A. (1992) Primary structure and functional characterisation of a high affinity glutamate transporter. Nature 360, 467471.
  • Kerkerian L., Dusticier N. and Nieoullon A. (1987) Modulatory effects of dopamine on high affinity glutamate uptake in rat striatum. J. Neurochem. 48, 13011306.
  • Krizman-Genda E., Gonzales M. I., Zelenaia O. and Robinson M. B. (2005) Evidence that Akt mediates platelet-derived growth factor-dependent increases in activity and surface expression of the neuronal glutamate transporter, EAAC1. Neuropharmacology 49, 872882.
  • Kugler P. and Schmitt A. (1999) Glutamate transporter EAAC1 is expressed in neurons and glial cells in the rat nervous system. Glia 27, 129142.
  • Levenson J., Weeber E., Selcher J. C., Kategaya L. S., Sweatt J. D. and Eskin A. (2002) Long-term potentiation and contextual fear conditioning increase neuronal glutamate uptake. Nat. Neurosci. 5, 155161.
  • Lievens J. C., Dutertre M., Forni C., Salin P. and Kerkerian-LeGoff L. (1997) Continuous administration of the glutamate uptake inhibitor 1-trans-pyrrolidine-2,4-dicarboxylate produces striatal lesions. Mol. Brain Res. 50, 909919.
  • Lin C. I., Orlov I., Ruggiero A. M., Dykes-Hoberg M., Lee A., Jackson M. and Rothstein J. D. (2001) Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. Nature 410, 8488.
  • Lipton S. A. (2006) Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat. Rev. Drug Discov. 5, 160170.
  • Lortet S., Samuel D., Had-Aissouni L., Masmejean F., Kerkerian-LeGoff L. and Pisano P. (1999) Effects of PKA and PKC modulators on high affinity glutamate uptake in primary neuronal cell cultures from rat cerebral cortex. Neuropharmacology 38, 395402.
  • Maragakis N. J. and Rothstein J. D. (2004) Glutamate transporters: animal models to neurologic diseases. Neurobiol. Dis. 15, 461473.
  • Martin L. J., Brambrink A. M., Lehmann C., Portera-Cailliau C., Koehler R., Rothstein J. D. and Traystman R. J. (1997) Hypoxia–ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in the newborn striatum. Ann. Neurol. 42, 335348.
  • Masliah E., Alford M., Mallory M., Rockenstein E., Moechars D. and Van Leuven F. (2000) Abnormal glutamate transport function in mutant amyloid precursor protein transgenic mice. Exp. Neurol. 163, 381387.
  • Mauch D. H., Nagler K., Schumacher S., Goritz C., Muller E. C., Otto A. and Pfriger F. W. (2001) CNS synaptogenesis promoted by glia-derived cholesterol. Science 294, 13541357.
  • Mineo C., Ying Y. S., Chapline C., Jaken S. and Anderson R. G. (1998) Targeting of protein kinase Calpha to caveola. J. Cell Biol. 141, 601610.
  • Mitrovic A. D., Amara S. G., Johnston G. A. R. and Vandenberg R. J. (1998) Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. J. Biol. Chem. 273, 14 69814 706.
  • Moghaddam B. (1993) Stress preferentially increases extraneuronal levels of excitatory amino acids in the prefrontal cortex: comparison to hippocampus and basal ganglia. J. Neurochem. 60, 16501657.
  • Molteni R., Ying Z. and Gomez-Pinilla F. (2002) Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray. Eur. J. Neurosci. 16, 11071116.
  • Nafia I., Ré D. B., Masmejean F., Salin P., Kerkerian-Le-Goff L. and Had-Aissouni L. (2005) Reversed glutamate transport triggers death of astrocytes and dopaminergic neurons in mesencephalic cultures through different mechanisms, in Soc. Neurosci. Abstr. 35, 154.10.
  • Najimi M., Malteaux J. M. and Hermans E. (2002) Cytosqueleton-related trafficking of the EAAC1 glutamate transporter after activation of the G(q/11)-coupled neurotensin receptor NTS1. J. Biol. Chem. 523, 224228.
  • Nieoullon A., Kerkerian L. and Dusticier N. (1983) Presynaptic dopaminergic control of high affinity glutamate uptake in the striatum. Neurosci. Lett. 43, 191196.
  • Peghini P., Janzen J. and Stoffel W. (1997) Glutamate transporter EAAC1-deficient mice develop dicarboxylic aminoaciduria and behavioral abnormalities but no neurodegeneration. EMBO J. 16, 38223832.
  • Pfriger F. W. and Barres B. A. (1997) Synaptic efficacy enhanced by glial cells in vitro. Science 277, 16841687.
  • Pines G., Danbolt N. C., Bjørås M., Zhang Y., Bendahan A., Eide L., Koepsell H., Storm-Mathisen J., Seeberg E. and Kanner B. I. (1992) Cloning and expression of a rat brain 1-glutamate transporter. Nature 360, 464467.
  • Pisano P., Samuel D., Nieoullon A. and Kerkerian-LeGoff L. (1996) Activation of the adenylate cyclase-dependent protein kinase pathway increases high affinity glutamate uptake into rat striatal synaptosomes. Neuropharmacology 35, 541547.
  • Rao V. L., Dogan A., Todd K. G., Bowen K. K., Kim B. T., Rothstein J. D. and Dempsey R. J. (2001) Antisense knockdown of the glial glutamate transporter GLT1 but not the neuronal glutamate transporter EAAC1 exacerbes transient focal cerebral ischemia-induced neuronal damage in rat brain. J. Neurosci. 21, 18761883.
  • Represa A. and Ben Ari Y. (2005) Trophic actions of GABA on neuronal development. Trends Neurosci. 28, 278283.
  • Robinson M. B. (2002) Regulated trafficking of neurotransmitter transporters: common notes, different melodies. J. Neurochem. 80, 111.
  • Rothstein J. D., Martin L., Levey A. I., Dykes-Hoberg M., Jin L., Wu D., Nash N. and Kuncl R. W. (1994) Localization of neuronal and glial glutamate transporters. Neuron 13, 713725.
  • Rothstein J. D., Van Kammen M., Levey A. I., Martin L. J. and Kuncl R. W. (1995) Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann. Neurol. 38, 7384.
  • Rothstein J. D., Dykes-Hoberg M., Pardo C. A. et al. (1996) Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron 16, 675686.
  • Ruggiero A. M., Vidensky S. and Rothstein J. D. (2003) GTRAP3-18 protein is able to regulate the activity of excitatory amino acid transporters (EAATs) through alteration in asn linked glycosyl processing. Soc. Neurosci. Abstr. 372.15.
  • Rusakov D. A. and Kullmann D. M. (1998) Extrasynaptic glutamate diffusion in the hippocampus: ultrastructural constraints, uptake, and receptor activation. J. Neurosci. 18, 31583170.
  • Saier M. H., Jr (2000) Families of proteins forming transmembrane channels. J. Membr. Biol. 175, 165180.
  • Sato H., Tamba M., Okuno S., Sato K., Keino-Masu K., Masu M. and Bannai S. (2002) Distribution of cystine/glutamate exchange transporter, system xc, in the mouse brain. J. Neurosci. 22, 80288033.
  • Sato H., Shiiya A., Kimata M. et al. (2005) Redox imbalance in cystine/glutamate transporter-deficient mice. J. Biol. Chem. 280, 37 42337 429.
  • Schulz J. B., Lindenau J., Seyfried J. and Dichgans J. (2000) Glutathione, oxidative stress and neurodegeneration. Eur. J. Biochem. 267, 49044911.
  • Seal R. P. and Amara S. G. (1999) Excitatory amino acid transporters: a family in flux. Annu. Rev. Pharmacol. Toxicol. 39, 431456.
  • Seal R. P., Leighton B. H. and Amara S. G. (2000) A model for the topology of excitatory amino acid transporters determined by the extracellular accessibility of substituted cysteines. Neuron 25, 695706.
  • Seifert G., Schilling K. and Steinhäuser C. (2006) Astrocyte dysfunction in neurological disorders: a molecular perspective. Nat. Rev. Neurosci. 7, 194206.
  • Sepkuty J. P., Cohen A. S., Eccles C., Rafiq A., Behar K., Ganel R., Coulter D. A. and Rothstein J. D. (2002) A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. J. Neurosci. 22, 63726379.
  • Shanker G., Allen J. W., Mutkus L. A. and Aschner M. (2001) The uptake of cysteine in cultured primary astrocytes and neurons. Brain Res. 902, 156163.
  • Shashidharan P., Huntley G. W., Murray J. M., Buku A., Moran T., Walsh M. J., Morrison J. H. and Plaitakis A. (1997) Immunohistochemical localization of the neuron-specific glutamate transporter EAAC1 (EAAT3) in rat brain and spinal cord revealed by a novel monoclonal antibody. Brain Res. 773, 139148.
  • Shigeri Y., Seal R. P. and Shimamoto K. (2004) Molecular pharmacology of glutamate transporters, EAATs and VGLUTs. Brain Res. Brain Res. Rev. 45, 250265.
  • Sims K. D. and Robinson M. B. (1999) Expression pattern and regulation of glutamate transporters in the developing and adult nervous system. Crit. Rev. Neurobiol. 13, 169197.
  • Sims K. D., Straff D. J. and Robinson M. B. (2000) Platelet-derived growth factor rapidly increases activity and cell surface expression of the EAAC1 subtype of glutamate transporter through activation of phosphatidylinositol 3-kinase. J. Biol. Chem. 275, 52285237.
  • Storck T., Schulte S., Hofmann K. and Stoffel W. (1992) Structure, expression, and functional analysis of a Na+-dependent glutamate/aspartate transporter from rat brain. Proc. Natl Acad. Sci. USA 89, 10 95510 959.
  • Torp R., Danbolt N. C., Balaie E., Bjoras M., Seeberg E., Storm-Mathisen J. and Ottersen O. P. (1994) Differential expression of two glial glutamate transporters in the rat brain: an in situ hybridization study. Eur. J. Neurosci. 6, 936942.
  • Trotti D., Aoki M., Pasinelli P., Berger U. V., Danbolt N. C., Brown R. H., Jr, and Hediger M. A. (2001a) Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity. J. Biol. Chem. 276, 576582.
  • Trotti D., Peng J. B., Dunlop J. and Hediger M. A. (2001b) Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters. Brain Res. 914, 196203.
  • Ullian E. M., Sapperstein S. K., Christopherson K. S. and Barres B. A. (2001) Control of synapse number by glia. Science 291, 657661.
  • Yang W. and Kilberg M. S. (2002) Biosynthesis, intracellular targeting and degradation of the EAAC1 glutamate/aspartate transporter in C6 glioma cells. J. Biol. Chem. 277, 38 35038 357.
  • Yang Y., Kinney G. A., Spain W. J., Breitner J. C. and Cook D. G. (2004) Presenilin-1 and intracellular calcium stores regulate neuronal glutamate uptake. J. Neurochem. 88, 13611372.
  • Yernool D., Boudker O., Folta-Stogniew E. and Gouaux E. (2003) Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus. Biochemistry 42, 12 98112 988.
  • Yernool D., Boudker O., Jin Y. and Gouaux E. (2004) Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature 431, 811818.
  • Zerangue N. and Kavanaugh M. P. (1996) Interaction of 1-cysteine with a human excitatory amino acid transporter. J. Physiol. 493, 419423.
  • Zhang G. J., Raol Y. S. H., Hsu F. C. and Brookskayal A. R. (2004) Long-term alterations in glutamate receptor and transporter expression following early-life seizures are associated with increased seizure susceptibility. J. Neurochem. 88, 91101.
  • Zhu Y., Fei J. and Schwarz W. (2005) Expression and transport function of the glutamate transporter EAAC1 in Xenopus oocytes is regulated by syntaxin 1A. J. Neurosci. Res. 79, 503508.