Leptin: a diverse regulator of neuronal function
Version of Record online: 23 AUG 2006
Journal of Neurochemistry
Volume 100, Issue 2, pages 307–313, January 2007
How to Cite
Harvey, J. (2007), Leptin: a diverse regulator of neuronal function. Journal of Neurochemistry, 100: 307–313. doi: 10.1111/j.1471-4159.2006.04205.x
- Issue online: 23 AUG 2006
- Version of Record online: 23 AUG 2006
- Received June 7, 2006; revised manuscript received August 1, 2006; accepted August 10, 2006.
- actin dynamics;
- large conductance Ca2+-activated K+ channel;
- long-term depression;
- phosphoinositide 3-kinase
It is well documented that leptin is a circulating hormone that plays a key role in regulating food intake and body weight via its actions on specific hypothalamic nuclei. However, leptin receptors are widely expressed in the CNS, in regions not generally associated with energy homeostasis, such as the hippocampus, cortex and cerebellum. Moreover, evidence is accumulating that leptin has widespread actions in the brain. In particular, recent studies have demonstrated that leptin markedly influences the excitability of hippocampal neurons via its ability to activate large conductance Ca2+-activated K+ (BK) channels, and also to promote long-term depression of excitatory synaptic transmission. Here, we review the evidence supporting a role for this hormone in regulating hippocampal excitability.