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  • Attoub S., Noe V., Pirola L., Bruyneel E., Chastre E., Mareel M., Wymann M. P. and Gespach C. (2000) Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. FASEB J. 14, 23292338.
  • Ayyildiz M., Yildirim M., Agar E. and Baltaci A. K. (2006) The effect of leptin on penicillin-induced epileptiform-like activity in rats. Brain Res. Bull. 68, 374378.
  • Banks W. A. (2001) Enhanced leptin transport across the blood–brain barrier by α1-adrenergic agents. Brain Res. 899, 209217.
  • Banks W. A. and Farrell C. L. (2003) Impaired transport of leptin across the blood–brain barrier in obesity is acquired and reversible. Am. J. Physiol. Endocrinol. Metab. 285, E10E15.
  • Banks W. A., Kastin A. J., Huang W., Jaspan J. B. and Maness L. M. (1996) Leptin enters the brain by a saturable system independent of insulin. Peptides 17, 305311.
  • Banks W. A., Clever C. M. and Farrell C. L. (2000) Partial saturation and regional variation in the blood-to-brain transport of leptin in normal weight mice. Am. J. Physiol. Endocrinol. Metab. 278, E1158E1165.
  • Banks W. A., Coon A. B., Robinson S. M., Moinuddin A., Shultz J. M., Nakaoke R. and Morley J. E. (2004) Triglycerides induce leptin resistance at the blood–brain barrier. Diabetes 53, 12531260.
  • Baumann H., Morella K. K., White D. W., Dembski M., Bailon P. S., Kim H., Lai C. F. and Tartaglia L. A. (1996) The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors. Proc. Natl Acad. Sci. USA 93, 83748378.
  • Behrens R., Nolting A., Reimann F., Schwartz M., Waldschutz R. and Pongs O. (2000) hKCNMB3 and hKCNMB4, cloning and characterisation of two members of the large-conductance calcium-activated potassium channel beta subunit family. FEBS lett. 474, 99106.
  • Bjorbaek C., Uotani S., Da Silva B. and Flier J. S. (1997) Divergent signaling capacities of the long and short isoforms of the leptin receptor. J. Biol. Chem. 272, 32 68632 695.
  • Bjorbaek C., Elmquist J. K., Michl P., Ahima R. S., Van Bueren A., McCall A. L. and Flier J. S. (1998) Expression of leptin receptor isoforms in rat brain microvessels. Endocrinology 139, 34853491.
  • Considine R. V., Considine E. L., Williams C. J., Hyde T. M. and Caro J. F. (1996) The hypothalamic leptin receptor in humans: identification of incidental sequence polymorphisms and absence of the db/db mouse and fa/fa rat mutations. Diabetes 45, 992994.
  • Devos R., Guisez Y., Van der Heyden J., White D. W., Kalai M., Fountoulakis M. and Plaetinck G. (1997) Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding. J. Biol. Chem. 272, 18 30418 310.
  • Durakoglugil M., Irving A. J. and Harvey J. (2005) Leptin induces a novel form of NMDA receptor-dependent long-term depression. J. Neurochem. 95, 396405.
  • Elmquist J. K., Bjorbaek C., Ahima R. S., Flier J. S. and Saper C. B. (1998) Distributions of leptin receptor mRNA isoforms in the rat brain. J. Comp. Neurol. 395, 535547.
  • Figlewicz D. P., Evans S. B., Murphy J., Hoen M. and Baskin D. G. (2003) Expression of receptors for insulin and leptin in the ventral tegmental area/substantia nigra (VTA/SN) of the rat. Brain Res. 964, 107115.
  • Golden P. L., Maccagnan T. J. and Pardridge W. M. (1997) Human blood–brain barrier leptin receptor. Binding and endocytosis in isolated human brain microvessels. J. Clin. Invest. 99, 1418.
  • Greene A. E., Todorova M. T. and Seyfried T. N. (2003) Perspectives on the metabolic management of epilepsy through dietary reduction of glucose and elevation of ketone bodies. J. Neurochem. 86, 529537.
  • Grill H. J., Schwartz M. W., Kaplan J. M., Foxhall J. S., Breininger J. and Baskin D. G. (2002) Evidence that the caudal brainstem is a target for the inhibitory effect of leptin on food intake. Endocrinology 143, 239246.
  • Hakansson M. L., Brown H., Ghilardi N., Skoda R. C. and Meister B. (1998) Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 18, 559572.
  • Harvey J. (2003) Leptin: a multifaceted hormone in the central nervous system. Mol. Neurobiol. 28, 245258.
  • Harvey J., Hardy S. C., Irving A. J. and Ashford M. L. (2000) Leptin activation of ATP-sensitive K+(KATP) channels in rat CRI. G1 insulinama cells involves disruption of the actin cytoskeleton. J. Physiol., 527, 95107.
  • Harvey J., McKenna F., Herson P. S., Spanswick D. and Ashford M. L. (1997) Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J. Physiol. 504, 527535.
  • Hegyi K., Fulop K., Kovacs K., Toth S. and Falus A. (2004) Leptin-induced signal transduction pathways. Cell Biol. Int. 28, 159169.
  • Heim M. H. (1996) The Jak-STAT pathway: specific signal transduction from the cell membrane to the nucleus. Eur. J. Clin. Invest. 26, 112.
  • Ihle J. N. (1995) Cytokine receptor signalling. Nature 377, 591594.
  • Irving A. J., Wallace L., Durakoglugil D. and Harvey J. (2006) Leptin enhances NR2B-mediated N-methyl-d-aspartate responses via a mitogen-activated protein kinase-dependent process in cerebellar granule cells. Neuroscience 138, 11371148.
  • Jacob R. J., Dziura J., Medwick M. B., Leone P., Caprio S., During M., Shulman G. I. and Sherwin R. S. (1997) The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus. Diabetes 46, 150152.
  • Janmey P. A., Xian W. and Flanagan L. A. (1999) Controlling cytoskeleton structure by phosphoinositide–protein interactions: phosphoinositide binding protein domains and effects of lipid packing. Chem. Phys. Lipids. 101, 93107.
  • Lee G., Li C., Montez J., Halaas J., Darvishzadeh J. and Friedman J. M. (1997) Leptin receptor mutations in 129 db3J/db3J mice and NIH facp/facp rats. Mamm. Genome 8, 445447.
  • Lee G. H., Proenca R., Montez J. M., Carroll K. M., Darvishzadeh J. G., Lee J. I. and Friedman J. M. (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 379, 632635.
  • Liu L., Wong T. P., Pozza M. F., Lingenhoehl K., Wang Y., Sheng M., Auberson Y. P. and Wang Y. T. (2004) Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science 304, 10211024.
  • Ludwig M. and Pittman Q. J. (2003) Talking back: dendritic neurotransmitter release. Trends Neurosci. 26, 255261.
  • Madej T., Boguski M. S. and Bryant S. H. (1995) Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Lett. 373, 1318.
  • Maffei M., Halaas J., Ravussin E. et al. (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat. Med. 1, 11551161.
  • Massey P. V., Johnson B. E., Moult P. R., Auberson Y. P., Brown M. W., Molnar E., Collingridge G. L. and Bashir Z. I. (2004) Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. J. Neurosci. 24, 78217828.
  • Meera P., Wallner M. and Toro L. (2000) A neuronal beta subunit (KCNMB4) makes the large conductance, voltage and Ca2+-activated K+ channel resistant to charybolotoxin and iberiotoxin. P.N.A.S. 97, 55625567.
  • Mercer J. G., Hoggard N., Williams L. M., Lawrence C. B., Hannah L. T. and Trayhurn P. (1996) Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387, 113116.
  • Mirshamsi S., Laidlaw H. A., Ning K., Anderson E., Burgess L. A., Gray A., Sutherland C. and Ashford M. L. (2004) Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurons: P13k dependent actin reorganisation and KATP channel activation. BMC Neurosci. 5, 54.
  • Morash B., Li A., Murphy P. R., Wilkinson M. and Ur E. (1999) Leptin gene expression in the brain and pituitary gland. Endocrinology 140, 59955998.
  • O'Malley D., Irving A. J. and Harvey J. (2005) Leptin-induced dynamic alterations in the actin cytoskeleton mediate the activation and synaptic clustering of BK channels. FASEB J. 19, 19171919.
  • Proulx K., Clavel S., Nault G., Richard D. and Walker C. D. (2001) High neonatal leptin exposure enhances brain GR expression and feedback efficacy on the adrenocortical axis of developing rats. Endocrinology 142, 46074616.
  • Savioz A., Charnay Y., Huguenin C., Graviou C., Greggio B. and Bouras C. (1997) Expression of leptin receptor mRNA (long form splice variant) in the human cerebellum. Neuroreport 8, 31233126.
  • Schwartz M. W., Seeley R. J., Campfield L. A., Burn P. and Baskin D. G. (1996a) Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 98, 11011106.
  • Schwartz M. W., Peskind E., Raskind M., Boyko E. J. and Porte D. Jr (1996b) Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat. Med. 2, 589593.
  • Shanley L. J., Irving A. J. and Harvey J. (2001) Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J. Neurosci. 21, RC186.
  • Shanley L. J., O'Malley D., Irving A. J., Ashford M. L. and Harvey J. (2002a) Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels. J. Physiol. 545, 933944.
  • Shanley L. J., Irving A. J., Rae M. G., Ashford M. L. and Harvey J. (2002b) Leptin inhibits rat hippocampal neurons via activation of large conductance calcium-activated K+ channels. Nat. Neurosci. 5, 299300.
  • Spanswick D., Smith M. A., Groppi V. E., Logan S. D. and Ashford M. L. (1997) Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390, 521525.
  • Spiegelman B. M. and Flier J. S. (2001) Obesity and the regulation of energy balance. Cell 104, 531543.
  • Takahashi K. A. and Cone R. D. (2005) Fasting induces a large, leptin-dependent increase in the intrinsic action potential frequency of orexigenic arcuate nucleus neuropeptide Y/Agouti-related protein neurons. Endocrinology 146, 10431047.
  • Tartaglia L. A., Dembski M., Weng X. et al. (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 12631271.
  • Toro L., Wallner M., Meera P. and Tanaka Y. (1998) Maxi-KCa, a unique member of the voltage-gated K channel superfamily. News Physiol. Sci. 13, 112117.
  • Ur E., Wilkinson D. A., Morash B. A. and Wilkinson M. (2002) Leptin immunoreactivity is localized to neurons in rat brain. Neuroendocrinology 75, 264272.
  • Wang J., Liu R., Hawkins M., Barzilai N. and Rossetti L. (1998) A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393, 684688.
  • Wayner M. J., Armstrong D. L., Phelix C. F. and Oomura Y. (2004) Orexin-A (hypocretin-1) and leptin enhance LTP in the dentate gyrus of rats in vivo. Peptides 25, 991996.
  • Williams K. W. and Smith B. N. (2006) Rapid inhibition of neural excitability in the nucleus tractus solitarii by leptin: implications for ingestive behaviour. J. Physiol. 573, 395412.
  • Yamashita T., Murakami T., Otani S., Kuwajima M. and Shima K. (1998) Leptin receptor signal transduction: OBRa and OBRb of fa type. Biochem. Biophys. Res. Commun. 246, 752759.
  • Zhang Y., Proenca R., Maffei M., Barone M., Leopold L. and Friedman J. M. (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425432.
  • Zhao A. Z., Shinohara M. M., Huang D., Shimizu M., Eldar-Finkelman H., Krebs E. G., Beavo J. A. and Bornfeldt K. E. (2000) Leptin induces insulin-like signaling that antagonizes cAMP elevation by glucagon in hepatocytes. J. Biol. Chem. 275, 11 34811 354.