Multiple sclerosis: a battle between destruction and repair
Article first published online: 5 OCT 2006
Journal of Neurochemistry
Volume 100, Issue 2, pages 295–306, January 2007
How to Cite
McQualter, J. L. and Bernard, C. C. A. (2007), Multiple sclerosis: a battle between destruction and repair. Journal of Neurochemistry, 100: 295–306. doi: 10.1111/j.1471-4159.2006.04232.x
- Issue published online: 5 OCT 2006
- Article first published online: 5 OCT 2006
- Received June 26, 2006; revised manuscript received August 23, 2006; accepted August 30, 2006.
- experimental autoimmune encephalomyelitis;
- multiple sclerosis;
- stem cells
Multiple sclerosis (MS) is a chronic neurodegenerative disease of the CNS in which an unrelenting attack from the innate and adaptive arms of the immune system results in extensive demyelination, loss of oligodendrocytes and axonal degeneration. This review summarizes advances in the understanding of the cellular and molecular pathways involved in neurodegeneration following autoimmune-mediated inflammation in the CNS. The mechanisms underlying myelin and axonal destruction and the equally important interaction between degenerative and repair mechanisms are discussed. Recent studies have revealed that the failure of CNS regeneration may be in part a result of the presence of myelin-associated growth inhibitory molecules in MS lesions. Successful therapeutic intervention in MS is likely to require suppression of the inflammatory response, in concert with blockade of growth inhibitory molecules and possibly the mobilization or transplantation of stem cells for regeneration.