Serotonin and neuronal growth factors – a convergence of signaling pathways
Version of Record online: 5 FEB 2007
Journal of Neurochemistry
Volume 101, Issue 5, pages 1161–1171, June 2007
How to Cite
Cowen, D. S. (2007), Serotonin and neuronal growth factors – a convergence of signaling pathways. Journal of Neurochemistry, 101: 1161–1171. doi: 10.1111/j.1471-4159.2006.04420.x
- Issue online: 5 FEB 2007
- Version of Record online: 5 FEB 2007
- Received October 5, 2006; revised manuscript received November 13, 2006; accepted December 3, 2006.
- brain-derived neurotrophic factor;
- extracellular-regulated kinase;
Monoamines, including serotonin (5-HT), have traditionally been associated with short-term signaling pathways in neurons, such as the modulation of cAMP and Ca2+ levels. In contrast, neuronal growth factors, such as neurotrophins, have been traditionally associated with signaling pathways, such as those for activation of extracellular-regulated kinase (ERK) and Akt (protein kinase B), which are known to induce long-term protective changes. It has therefore been unclear how antidepressants that increase serotonin (5-HT), induce such changes as hippocampal neuroprotection and neurogenesis. It has been hypothesized, that the actions of 5-HT may be mediated indirectly through increased synthesis of peptide growth factors. However, there is increasing evidence that some subtypes of 5-HT receptors can directly couple to activation of the ERK and Akt pathways. Such coupling suggests a more direct potential role for 5-HT in mediating the long-term actions induced by antidepressants.