Molecular regulation of cognitive functions and developmental plasticity: impact of GABAA receptors
Article first published online: 22 JAN 2007
Journal of Neurochemistry
Volume 102, Issue 1, pages 1–12, July 2007
How to Cite
Möhler, H. (2007), Molecular regulation of cognitive functions and developmental plasticity: impact of GABAA receptors. Journal of Neurochemistry, 102: 1–12. doi: 10.1111/j.1471-4159.2007.04454.x
- Issue published online: 22 JAN 2007
- Article first published online: 22 JAN 2007
- Received April 11, 2006; revised manuscript received December 20, 2006; accepted December 22, 2006.
- sensory processing;
By controlling spike timing and sculpting neuronal rhythms, inhibitory interneurons play a key role in regulating neuronal circuits and behavior. The pronounced diversity of GABAergic (γ-aminobutyric acid) interneurons is paralleled by an extensive diversity of GABAA receptor subtypes. The region- and domain-specific location of these receptor subtypes offers the opportunity to gain functional insights into the role of defined neuronal circuits. These developments are reviewed with regard to the regulation of sleep, anxiety, memory, sensorimotor processing and post-natal developmental plasticity.