Increased stem cell proliferation in the spinal cord of adult amyotrophic lateral sclerosis transgenic mice

Authors

  • Ying-jun Guan,

    1. Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    2. Weifang Medical College, Weifang, Shandong, China
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    • 1

      These authors have made equal contributions.

  • Xin Wang,

    1. Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
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    • 1

      These authors have made equal contributions.

  • Hong-yan Wang,

    1. Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
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  • Kyutaro Kawagishi,

    1. Institute of Neuroscience and Physiology, Sahlgrenska Academy at Göteborg University, Medicinaregatan, Göteborg, Sweden
    2. Department of Anatomy, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
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  • Hoon Ryu,

    1. Departments of Neurology, Pathology, and Psychiatry, Boston University School of Medicine, Boston, Massachusetts, USA
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  • Chun-feng Huo,

    1. Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
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  • Ethan M. Shimony,

    1. Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
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  • Bruce S. Kristal,

    1. Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
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  • Hans-Georg Kuhn,

    1. Institute of Neuroscience and Physiology, Sahlgrenska Academy at Göteborg University, Medicinaregatan, Göteborg, Sweden
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  • Robert M. Friedlander

    1. Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts, USA
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Address correspondence and reprint requests to Dr Robert M. Friedlander, Neuroapoptosis Laboratory, Department of Neurosurgery, Brigham and Women’s Hospital, Harvard Medical School, LMRC 123, Boston, MA 02115, USA. E-mail: rfriedlander@rics.bwh.harvard.edu

Abstract

Harnessing the regenerative potential of the central nervous system to repopulate depleted cellular populations from endogenous stem cells would be a novel approach for the treatment of neurological diseases resulting from cell death. Consequently, understanding if and how the central nervous system is capable of such regeneration would determine if such an approach is feasible. In this report, we provide evidence of widespread regenerative response in the spinal cord of amyotrophic lateral sclerosis transgenic mice. However, this regenerative response appears to be largely unproductive. We demonstrate that there is significantly increased gliogenesis, but an absence of convincing neurogenesis. The fact that the neurodegenerative process stimulates a regenerative response suggests that the adult spinal cord has at least limited ability for regeneration. Further studies will determine if this endogenous regenerative process can be enhanced and directed so as to slow or even reverse the natural progression of this devastating disease.

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