SEARCH

SEARCH BY CITATION

References

  • Abe T., Kakyo M., Sakagami H. et al. (1998) Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J. Biol. Chem. 273, 2239522401.
  • Asaba H., Hosoya K., Takanaga H., Ohtsuki S., Tamura E., Takizawa T. and Terasaki T. (2000) Blood-brain barrier is involved in the efflux transport of a neuroactive steroid, dehydroepiandrosterone sulfate, via organic anion transporting polypeptide 2. J. Neurochem. 75, 19071916.
  • Bjorkhem I., Lutjohann D., Breuer O., Sakinis A. and Wennmalm A. (1997) Importance of a novel oxidative mechanism for elimination of brain cholesterol. J. Biol. Chem. 272, 3017830184.
  • Bjorkhem I., Lutjohann D., Diczfalusy U., Stahle L., Ahlborg G. and Wahren J. (1998) Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation. J. Lipid Res. 39, 15941600.
  • Fukumoto H., Deng A., Irizarry M. C., Fitzgerald M. L. and Rebeck G. W. (2002) Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels. J. Biol. Chem. 277, 4850848513.
  • Gao B., Stieger B., Noe B., Fritschy J. M. and Meier P. J. (1999) Localization of the organic anion transporting polypeptide 2 (Oatp2) in capillary endothelium and choroid plexus epithelium of rat brain. J. Histochem. Cytochem. 47, 12551264.
  • Gao B., Hagenbuch B., Kullak-Ublick G. A., Benke D., Aguzzi A. and Meier P. J. (2000) Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J. Pharmacol. Exp. Ther. 294, 7379.
  • Golanska E., Hulas-Bigoszewska K., Wojcik I. et al. (2005) CYP46: a risk factor for Alzheimer’s disease or a coincidence? Neurosci. Lett. 383, 105108.
  • Hagenbuch B. and Meier P. J. (2004) Organic anion transporting polypeptides of the OATP/SLC21 family: phylogenetic classification as OATP/SLCO superfamily, new nomenclature and molecular/functional properties. Pflugers Arch. 447, 653665.
  • Hori S., Ohtsuki S., Tachikawa M., Kimura N., Kondo T., Watanabe M., Nakashima E. and Terasaki T. (2004) Functional expression of rat ABCG2 on the luminal side of brain capillaries and its enhancement by astrocyte-derived soluble factor(s). J. Neurochem. 90, 526536.
  • Imai Y., Asada S., Tsukahara S., Ishikawa E., Tsuruo T. and Sugimoto Y. (2003) Breast cancer resistance protein exports sulfated estrogens but not free estrogens. Mol. Pharmacol. 64, 610618.
  • Ingelsson M., Jesneck J., Irizarry M. C., Hyman B. T. and Rebeck G. W. (2004) Lack of association of the cholesterol 24-hydroxylase (CYP46) intron 2 polymorphism with Alzheimer’s disease. Neurosci. Lett. 367, 228231.
  • Kakee A., Terasaki T. and Sugiyama Y. (1996) Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier. J. Pharmacol. Exp. Ther. 277, 15501559.
  • Kakee A., Takanaga H., Terasaki T., Naito M., Tsuruo T. and Sugiyama Y. (2001) Efflux of a suppressive neurotransmitter, GABA, across the blood-brain barrier. J. Neurochem. 79, 110118.
  • Kolsch H., Ludwig M., Lutjohann D. and Rao M. L. (2001) Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. J Neural Transm 108, 475488.
  • Kusuhara H., Sekine T., Utsunomiya-Tate N., Tsuda M., Kojima R., Cha S. H., Sugiyama Y., Kanai Y. and Endou H. (1999) Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J. Biol. Chem. 274, 1367513680.
  • Lam P., Wang R. and Ling V. (2005) Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice. Biochemistry 44, 1259812605.
  • Leggas M., Adachi M., Scheffer G. L. et al. (2004) Mrp4 confers resistance to topotecan and protects the brain from chemotherapy. Mol. Cell. Biol. 24, 76127621.
  • Li L., Meier P. J. and Ballatori N. (2000) Oatp2 mediates bidirectional organic solute transport: a role for intracellular glutathione. Mol. Pharmacol. 58, 335340.
  • Liang Y., Lin S., Beyer T. P. et al. (2004) A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes. J. Neurochem. 88, 623634.
  • Lund E. G., Guileyardo J. M. and Russell D. W. (1999) cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain. Proc. Natl Acad. Sci. USA 96, 72387243.
  • Meaney S., Bodin K., Diczfalusy U. and Bjorkhem I. (2002) On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation: critical importance of the position of the oxygen function. J. Lipid Res. 43, 21302135.
  • Mori S., Takanaga H., Ohtsuki S., Deguchi T., Kang Y. S., Hosoya K. and Terasaki T. (2003) Rat organic anion transporter 3 (rOAT3) is responsible for brain-to-blood efflux of homovanillic acid at the abluminal membrane of brain capillary endothelial cells. J. Cereb. Blood Flow Metab. 23, 432440.
  • Mori S., Ohtsuki S., Takanaga H., Kikkawa T., Kang Y. S. and Terasaki T. (2004) Organic anion transporter 3 is involved in the brain-to-blood efflux transport of thiopurine nucleobase analogs. J. Neurochem. 90, 931941.
  • Noe B., Hagenbuch B., Stieger B. and Meier P. J. (1997) Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc. Natl Acad. Sci. USA 94, 1034610350.
  • Ohtsuki S. (2004) New aspects of the blood-brain barrier transporters; its physiological roles in the central nervous system. Biol. Pharm. Bull. 27, 14891496.
  • Ohtsuki S., Asaba H., Takanaga H., Deguchi T., Hosoya K., Otagiri M. and Terasaki T. (2002) Role of blood-brain barrier organic anion transporter 3 (OAT3) in the efflux of indoxyl sulfate, a uremic toxin: its involvement in neurotransmitter metabolite clearance from the brain. J. Neurochem. 83, 5766.
  • Ohtsuki S., Kikkawa T., Mori S., Hori S., Takanaga H., Otagiri M. and Terasaki T. (2004) Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J. Pharmacol. Exp. Ther. 309, 12731281.
  • Panzenboeck U., Balazs Z., Sovic A., Hrzenjak A., Levak-Frank S., Wintersperger A., Malle E. and Sattler W. (2002) ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells. J. Biol. Chem. 277, 4278142789.
  • Papassotiropoulos A., Lutjohann D., Bagli M., Locatelli S., Jessen F., Buschfort R., Ptok U., Bjorkhem I., Von Bergmann K. and Heun R. (2002) 24S-hydroxycholesterol in cerebrospinal fluid is elevated in early stages of dementia. J. Psychiatr. Res. 36, 2732.
  • Pfrieger F. W. (2003) Outsourcing in the brain: do neurons depend on cholesterol delivery by astrocytes? Bioessays 25, 7278.
  • Schinkel A. H., Wagenaar E., Van Deemter L., Mol C. A. and Borst P. (1995) Absence of the mdr1a p-glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. J. Clin. Invest. 96, 16981705.
  • Schonknecht P., Lutjohann D., Pantel J., Bardenheuer H., Hartmann T., Von Bergmann K., Beyreuther K. and Schroder J. (2002) Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer’s disease compared to healthy controls. Neurosci. Lett. 324, 8385.
  • Shiiki T., Ohtsuki S., Kurihara A., Naganuma H., Nishimura K., Tachikawa M., Hosoya K. and Terasaki T. (2004) Brain insulin impairs amyloid-beta(1-40) clearance from the brain. J. Neurosci. 24, 96329637.
  • Sugiyama D., Kusuhara H., Shitara Y., Abe T., Meier P. J., Sekine T., Endou H., Suzuki H. and Sugiyama Y. (2001) Characterization of the efflux transport of 17beta-estradiol-D-17beta-glucuronide from the brain across the blood-brain barrier. J. Pharmacol. Exp. Ther. 298, 316322.
  • Wakayama K., Ohtsuki S., Takanaga H., Hosoya K. and Terasaki T. (2002) Localization of norepinephrine and serotonin transporter in mouse brain capillary endothelial cells. Neurosci. Res. 44, 173180.
  • Wang L., Schuster G. U., Hultenby K., Zhang Q., Andersson S. and Gustafsson J. A. (2002) Liver X receptors in the central nervous system: from lipid homeostasis to neuronal degeneration. Proc. Natl Acad. Sci. USA 99, 1387813883.
  • Wang B., Zhang C., Zheng W., Lu Z., Zheng C., Yang Z., Wang L. and Jin F. (2004) Association between a T/C polymorphism in intron 2 of cholesterol 24S-hydroxylase gene and Alzheimer’s disease in Chinese. Neurosci. Lett. 369, 104107.
  • Whitney K. D., Watson M. A., Collins J. L., Benson W. G., Stone T. M., Numerick M. J., Tippin T. K., Wilson J. G., Winegar D. A. and Kliewer S. A. (2002) Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system. Mol. Endocrinol. 16, 13781385.
  • Yamaoka K., Tanigawara Y., Nakagawa T. and Uno T. (1981) A pharmacokinetics analysis program (MULTI) for microcomputer. J. Pharmacobiodyn. 4, 879885.
  • Zelcer N., Reid G., Wielinga P., Kuil A., Van Der Heijden I., Schuetz J. D. and Borst P. (2003) Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4). Biochem. J. 371, 361367.